Synthesis and study of antimicrobial activity of quaternary ammonium benzofuroxan salts

被引：7

作者：

Chugunova, Elena A. ^{[1
]}

Akylbekov, Nurgali I. ^{[2
]}

Mahrous, Essam M. ^{[2
]}

Voloshina, Alexandra D. ^{[1
]}

Kulik, Natalia V. ^{[1
]}

Zobov, Vladimir V. ^{[1
]}

Strelnik, Anna G. ^{[1
]}

Gerasimova, Tatiana P. ^{[1
]}

Dobrynin, Alexey B. ^{[1
]}

Burilov, Alexander R. ^{[1
]}

机构：

[1] Russian Acad Sci, AE Arbuzov Inst Organ & Phys Chem, Kazan Sci Ctr, Kazan, Russia

[2] Kazan Natl Res Technol Univ, Kazan, Russia

来源：

MONATSHEFTE FUR CHEMIE | 2018年 / 149卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

Halogenides; Heterocycles; Spectroscopy; Tautomerism; Quantum-chemical calculations; Drug research; NITRIC-OXIDE; STRUCTURAL HYBRIDS; NANOPARTICLES; DERIVATIVES;

D O I：

10.1007/s00706-017-2052-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It was found that quaternary ammonium salts of benzofuroxan based on o-, m-, and p-dibromoxylenes are formed as a mixture of two tautomers. Only one bromomethyl group participates in the quaternization of benzofuroxan with different dibromoxylenes. Bacteriostatic activity of the most active mixture of tautomers was two and four times higher than the reference drug, chloramphenicol, with respect to Staphylococcus aureus 209p and Bacillus cereus 8035, correspondingly. Hemolysis of these compounds does not exceed 1%, i.e., such compounds are not toxic. [GRAPHICS]

引用

页码：119 / 126

页数：8

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