Sequence variants in the bovine silent information regulator 6, their linkage and their associations with body measurements and carcass quality traits in Qinchuan cattle

被引：12
|
作者：
Gui, Linsheng [1 ]
Jiang, Bijie [1 ]
Zhang, Yaran [1 ]
Zan, Linsen [1 ,2 ]
机构：
[1] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
[2] Northwest A&F Univ, Natl Beef Cattle Improvement Ctr, Yangling 712100, Shaanxi, Peoples R China
来源：
GENE | 2015年 / 559卷 / 01期
关键词：
SIRT6; gene; Molecular markers; Haplotype; Beef quality; MAMMALIAN SIRTUINS; GROWTH TRAITS; SIRT6; GENE; POLYMORPHISMS; CONSTRUCTION; RESTRICTION; DISEASE;
D O I：
10.1016/j.gene.2015.01.008
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Silent information regulator 6 (SIRT6) belongs to the family of class III nicotinamide adenine dinucleotide (NAD)dependent deacetylase and plays an essential role in DNA repair and metabolism. This study was conducted to detect potential polymorphisms of the bovine SIRT6 gene and explore their relationships with body measurement and carcass quality in Qinchuan cattle. Four sequence variants (SVs) were identified in intron 6, exon 7, exon 9, and 3' UTR, via sequencing technology conducted in 468 individual Qinchuan cattle. Eleven different haplotypes were identified, of which two major haplotypes had a frequency of 45.7% (-CACT-) and 14.8% (-CGTC-). Three SVs (SV2, SV3 and SV4) were significantly associated with some of the body measurements and carcass quality traits (P < 0.05 or P <0.01), and the H2H7 (CC-GA-TT-TC) diplotype had better performance than other combinations. Our results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS) and management in beef cattle breeding programs. (C) 2015 Elsevier B.V. All rights reserved.
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页码：16 / 21
页数：6
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