Antibacterial effect of phenyl fatty hydroxamic acids synthesized from canola oil

被引：0

作者：

Jahangirian, Hossein ^{[1
]}

Haron, Jelas ^{[1
]}

Silong, Sidik ^{[1
]}

Yusof, Nor Azah ^{[1
]}

Shameli, Kamyar ^{[1
]}

Eissazadeh, Samira ^{[2
]}

Moghaddam, Roshanak Rafiee ^{[3
]}

Mahdavi, Behnam ^{[3
]}

Jafarzade, Mahtab ^{[4
]}

机构：

[1] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Cellular & Mol Biol, Serdang 43400, Selangor, Malaysia

[3] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Chem Sci & Food Technol, Ukm Bangi 43600, Selangor, Malaysia

[4] Univ Kebangsaan Malaysia, Fac Biosci & Biotechnol, Ukm Bangi 43600, Selangor, Malaysia

来源：

JOURNAL OF MEDICINAL PLANTS RESEARCH | 2011年 / 5卷 / 19期

关键词：

Antibacterial activity; phenyl fatty hydroxamic acids; canola oil; enzymatic reaction; ANTIMICROBIAL ACTIVITY; LIPASE; GROWTH;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phenyl fatty hydroxamic acids (PFHAs) were synthesized in a biphasic organic/aqueous medium from canola oil and phenyl hydroxylamine (PHA). The reaction was carried out in a sealed flask, incubated in water batch shaker at 39 degrees C for 72 h and catalyzed by immobilised lipase (Lipozyme TL IM). The products were then separated by filtration, solvent extraction followed by evaporation of the solvent. Elemental analysis, (1)H NMR (hydrogen nuclear magnetic resonance) and FTIR (Fourier transform infrared) spectra showed that PFHAs were produced from the reaction of PHA and canola oil. The antibacterial activity of PFHAs dissolved in hexane were investigated against gram-positive (that is, Staphylococcus aureus) and gram-negative bacteria (that is, Escherichia coli) by the disk and well diffusion methods using Mueller-Hinton Agar (MHA). The results showed that PFHAs have high antibacterial activity and their antibacterial property on E. coli is stronger than on S. aureus. The antibacterial property of PFHAs increased with the increase in PFHAs concentration.

引用

页码：4826 / 4831

页数：6

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