Emergence of carbapenem resistance in Pseudomonas aeruginosa isolates from a patient with cystic fibrosis in the absence of carbapenem therapy

被引：22

作者：

Wolter, Daniel J. ^{[1
]}

Acquazzino, Dee ^{[2
]}

Goering, Richard V. ^{[1
]}

Sammut, Paul ^{[2
]}

Khalaf, Noha ^{[1
]}

Hanson, Nancy D. ^{[1
]}

机构：

[1] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Ctr Res Antiinfect & Biotechnol, Omaha, NE 68178 USA

[2] Univ Nebraska Med Ctr, Dept Pediat, Div Pulm Cyst Fibrosis, Omaha, NE USA

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 46卷 / 12期

关键词：

D O I：

10.1086/588484

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was observed in the absence of carbapenem treatment. These data suggest that chronic exposure to unrelated drug classes may be an important determinant for the emergence of carbapenem resistance in P. aeruginosa.

引用

页码：E137 / E141

页数：5

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