Channel-forming activity of alamethicin: Effects of covalent tethering

被引：26
|
作者：
Woolley, G. Andrew [1 ]
机构：
[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 06期
关键词：
D O I：
10.1002/cbdv.200790113
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this short review article, the effects of covalent tethering of alamethicin molecules on channel-forming behavior are described. Broadly speaking, these chemical modifications have provided insight into all three aspects of channel behavior: the structure of the conducting state, the ion-selectivity and ion-permeation properties, and the voltage dependence. Each of these aspects are discussed in turn.
引用
收藏
页码：1323 / 1337
页数：15
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