Atherosclerotic Renal Artery Stenosis: Review of Pathophysiology, Clinical Trial Evidence, and Management Strategies

Renal artery stenosis is prevalent and commonly encountered by cardiovascular specialists. Recently published randomized studies have provoked tremendous controversies in the treatment strategy with regard to renal artery stenting. However, these studies are inconclusive because of major study limitations. As such, cardiovascular specialists are uncertain of the indications or utility of renal revascularization, with differing opinions on management by nephrologists and cardiologists. A greater understanding of this disease process, especially with regard to its functional significance and consequence and treatment strategies based on well-designed clinical trials, is sorely needed. Our review focuses on atherosclerotic renal artery stenosis, with an emphasis on indications for revascularization and review of current trial data.