Generation of α-Imin Gold Carbenes through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides

被引：244

作者：

Shu, Chao ^{[1
]}

Wang, Yong-Heng ^{[1
]}

Zhou, Bo ^{[1
]}

Li, Xin-Ling ^{[1
]}

Ping, Yi-Fan ^{[1
]}

Lu, Xin ^{[1
]}

Ye, Long-Wu ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China

[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 30期

关键词：

SELECTIVE SYNTHESIS; CASCADE REACTIONS; TRANSANNULATION; AMIDATION; AMINOCYCLOPROPANES; CONSTRUCTION; 2H-AZIRINES; AMINATION; PYRIDINES; OXAZOLES;

D O I：

10.1021/jacs.5b06015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The generation of a-imino gold carbenes via gold-catalyzed intermolecular reaction of azides and ynamides is disclosed. This new methodology allows for highly regioselective access to valuable 2,aminoindoles and 3-amino-beta-carbolines in generally good to excellent yields. A mechanistic rationale for this tandem reaction, especially for the observed high regioselectivity, is supported by DFT calculations.

引用

页码：9567 / 9570

页数：4

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