Generation of α-Imin Gold Carbenes through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides

被引：244
|
作者：
Shu, Chao [1 ]
Wang, Yong-Heng [1 ]
Zhou, Bo [1 ]
Li, Xin-Ling [1 ]
Ping, Yi-Fan [1 ]
Lu, Xin [1 ]
Ye, Long-Wu [1 ,2 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China
[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 30期
关键词：
SELECTIVE SYNTHESIS; CASCADE REACTIONS; TRANSANNULATION; AMIDATION; AMINOCYCLOPROPANES; CONSTRUCTION; 2H-AZIRINES; AMINATION; PYRIDINES; OXAZOLES;
D O I：
10.1021/jacs.5b06015
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The generation of a-imino gold carbenes via gold-catalyzed intermolecular reaction of azides and ynamides is disclosed. This new methodology allows for highly regioselective access to valuable 2,aminoindoles and 3-amino-beta-carbolines in generally good to excellent yields. A mechanistic rationale for this tandem reaction, especially for the observed high regioselectivity, is supported by DFT calculations.
引用
收藏
页码：9567 / 9570
页数：4
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