Management of diabetes mellitus in patients with cirrhosis: An overview and joint statement

被引：31

作者：

Boursier, Jerome ^{[1
,2
]}

Anty, Rodolphe ^{[3
,4
,5
]}

Carette, Claire ^{[6
]}

Cariou, Bertrand ^{[7
]}

Castera, Laurent ^{[8
,9
]}

Caussy, Cyrielle ^{[10
,11
]}

Fontaine, Helene ^{[12
]}

Garioud, Armand ^{[13
]}

Gourdy, Pierre ^{[14
,15
]}

Guerci, Bruno ^{[16
,17
]}

Guillaume, Maeva ^{[18
,19
]}

Michot, Niasha ^{[20
]}

Minello, Anne ^{[21
]}

Ouizeman, Dann J. ^{[3
]}

Serfaty, Lawrence ^{[22
]}

Bonnet, Fabrice ^{[23
]}

Verges, Bruno ^{[24
,25
]}

Petit, Jean-Michel ^{[24
,25
]}

机构：

[1] Univ Angers, Lab HIFIH, Angers, France

[2] CHU Angers, Serv Hepatogastroenterol & Oncol Digest, Angers, France

[3] CHU Nice, Digest Ctr, Nice, France

[4] INSERM, U1065, Team Complicat Hepat Obesite 8, Nice, France

[5] Univ Cote Azur, Fac Med, Nice, France

[6] Univ Paris, Hop Europeen Georges Pompidou, AP HP Ctr, Serv Nutr,Ctr Specialise Obesite CSO Ile de Franc, Paris, France

[7] Univ Nantes, CHU Nantes, INSERM, CNRS,Inst Thorax, F-44000 Nantes, France

[8] Hop Beaujon, AP HP, Dept Hepatol, Clichy, France

[9] Univ Paris, INSERM UMR 1149, Ctr Rech Sur Inflammat Paris Montmartre, Clichy, France

[10] Univ Claude Bernard Lyon 1, Univ Lyon, INSERM, INRA,INSA Lyon,CarMen Lab, F-69495 Pierre Benite, France

[11] Hosp Civils Lyon, Hop Lyon Sud, Dept Endocrinol Diabet & Nutr, F-69495 Pierre Benite, France

[12] Hop Cochin, AP HP, Unite Hepatol, Paris, France

[13] Ctr Hosp Intercommunal, GHT Confluences, ANGH, Serv Hepatogastroenterol, Villeneuve St Georges, France

[14] CHU Toulouse, Serv Diabetol Malad Metab & Nutr, Toulouse, France

[15] Univ Toulouse 3, INSERM UPS, UMR1297, Inst Malad Metab & Cardiovasc, Toulouse, France

[16] Hop Brabois, Dept Endocrinol Diabetol & Nutr, F-54500 Vandoeuvre Les Nancy, France

[17] Univ Lorraine, F-54500 Vandoeuvre Les Nancy, France

[18] Digest Ctr, Clin Pasteur, Toulouse, France

[19] INSERM, U1048, Equipe 9, Toulouse, France

[20] CHRU Nancy, Unite Assistance Nutr, Nancy, France

[21] Hop Univ Francois Mitterrand, Dept Gastroenterol & Hepatol, Dijon, France

[22] Hop Univ Strasbourg, Hop Hautepierre, Serv Hepatogastroenterol, Strasbourg, France

[23] Univ Rennes 1, CHU Rennes, Dept Endocrinol Diabetol & Nutr, Rennes, France

[24] Hop Univ Dijon, Dept Endocrinol Diabetol & Malad Metab, Dijon, France

[25] INSERM LNC UMR1231, Dijon, France

来源：

DIABETES & METABOLISM | 2021年 / 47卷 / 05期

关键词：

Cirrhosis; Diagnosis; Epidemiology; Monitoring; Pharmacological treatment; Type 2 diabetes mellitus; SINGLE-DOSE PHARMACOKINETICS; PLACEBO-CONTROLLED TRIAL; GLUCOSE-TOLERANCE TEST; CHRONIC LIVER-DISEASES; CLINICAL-IMPLICATIONS; HEPATIC IMPAIRMENT; GLYCATED HEMOGLOBIN; SAFETY PROFILE; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1016/j.diabet.2021.101272

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus (T2DM) is a frequent comorbidity in patients with cirrhosis that is projected to rise in prevalence due to the worldwide burden of obesity, insulin-resistance and non-alcoholic fatty liver disease. The management of T2DM in patients with cirrhosis is complex given the requirement for accurate adaptation according to the level of liver function impairment, with lack of summary of the little evidence available in the literature. Here, we summarise the data available with respect to the epidemiology and the impact of T2DM in patients with cirrhosis, as well as those on the management of T2DM in these patients. We provide guidance for the diagnosis of T2DM and the monitoring of glycaemic control in patients with cirrhosis, and for the management of nutrition and pharmacological treatments in relation to the level of liver dysfunction. (C) 2021 Elsevier Masson SAS. All rights reserved.

引用

页数：14

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