New bidentate alkoxy-NHC ligands for enantioselective copper-catalysed conjugate addition

被引：110
|
作者：
Clavier, H [1 ]
Coutable, L [1 ]
Guillemin, JC [1 ]
Mauduit, M [1 ]
机构：
[1] Ecole Natl Super Chim Rennes, Inst Chim Rennes, CNRS,UMR 6052, Lab Synth & Act Biomol, F-35700 Rennes, France
来源：
TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 05期
关键词：
D O I：
10.1016/j.tetasy.2005.01.015
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Chiral alkoxy-imidazolinium salts are easily available via a five-step procedure starting from beta-aminoalcohols. This new family of alkoxy-N-heterocyclic carbene (NHC) precursors is shown to be highly active in the enantioselective copper-catalysed conjugate addition to cyclic enones. Complete conversion with low catalyst loading and good enantiomeric excesses up to 93% were obtained at room temperature. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：921 / 924
页数：4
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