Rare Fungal Keratitis Caused by Coprinellus Radians

被引：5
|
作者：
Lu, Xiuhai [1 ]
Wang, Xin [1 ]
Zhang, Li [1 ]
Li, Xiaofeng [1 ]
Qi, Xiaolin [1 ]
机构：
[1] Shandong Acad Med Sci, Shandong Eye Inst, Shandong Eye Hosp, 372 Jingsi Rd, Jinan 250000, Peoples R China
来源：
MYCOPATHOLOGIA | 2020年 / 185卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Fungal keratitis; Coprinellus radians; In vitro antifungal susceptibility test; ANTIFUNGAL SUSCEPTIBILITY;
D O I：
10.1007/s11046-019-00414-y
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A case of fungal keratitis due to Coprinellus radians is reported. To our knowledge, fungal keratitis caused by this species was rare. Fungal hyphae were detected in corneal scrapings, and isolates were identified by morphology and by sequencing the internal transcribed spacer region of ribosomal DNA. The patient was treated with systemic and local antifungal therapy for 5 days, and lamellar keratoplasty was performed after no obvious improvement in symptoms. The in vitro antifungal susceptibilities of the case strain were tested for six antifungal agents. The results showed that 5-fluorouracil was resistant, fluconazole was moderately sensitive, and the other drugs assayed (amphotericin B, posaconazole, itraconazole and voriconazole) were highly effective against this fungus.
引用
收藏
页码：389 / 394
页数：6
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