Advanced pancreatic cancer successfully treated with continuous infusion of 5-fluorouracil and low-dose cisplatin

被引：2
|
作者：
Kikuchi, H
Ujiie, S
Kanamaru, R
机构：
[1] Miyagi Canc Ctr, Res Inst, Div Pharmacotherapy, Natori, Miyagi 9811293, Japan
[2] Tohoku Univ, Res Inst Dev Aging & Canc, Dept Clin Oncol, Sendai, Miyagi 980, Japan
来源：
INTERNAL MEDICINE | 1998年 / 37卷 / 07期
关键词：
combination chemotherapy; survival time;
D O I：
10.2169/internalmedicine.37.635
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Due to pyloric stenosis in a 59-year-old male with the diagnosis of unresectable pancreatic head cancer, gastro-jejunostomy and cholecysto-jejunostomy were performed. Following the operation, the patient underwent a combination chemotherapy with cisplatin 10 mg/day x 5/week and continuous infusion of 5-fluorouracil 500 mg/day for 4 weeks. After three courses, the tumor size decreased and the serum carcinoembryonic antigen (CEA) level decreased from 89.6 to 4.2 ng/ml without significant adverse effects. During the follow-up, the CEA increased and the patient is now receiving the same treatment, surviving for more than one year.
引用
收藏
页码：635 / 637
页数：3
相关论文
共 50 条
  • [11] Concurrent chemoradiotherapy for locally advanced esophageal cancer - A pilot study by using daily low-dose cisplatin and continuous infusion of 5-fluorouracil
    Hsu, CH
    Yeh, KH
    Lui, LT
    Lee, YC
    Bu, CF
    Wang, HP
    Lin, JT
    Cheng, AL
    ANTICANCER RESEARCH, 1999, 19 (5C) : 4463 - 4467
  • [12] LOW-DOSE CONTINUOUS INFUSION 5-FLUOROURACIL AND CISPLATIN - PHASE-II EVALUATION IN ADVANCED COLORECTAL-CARCINOMA
    LORUSSO, P
    PAZDUR, R
    REDMAN, BG
    KINZIE, J
    VAITKEVICIUS, V
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1989, 12 (06): : 486 - 490
  • [13] Concurrent chemoradiotherapy in esophageal cancer; Comparison between intermittent high dose cisplatin with 5-fluorouracil and daily low dose cisplatin with continuous low dose infusion of 5-fluorouracil
    Sal, H
    Mitsumori, M
    Araki, N
    Okumura, S
    Nishimura, Y
    Hiraoka, M
    RADIOLOGY, 2002, 225 : 415 - 415
  • [14] A randomized study of arterial infusion chemotherapy for hepatocellular carcinoma: Low-dose 5-fluorouracil/cisplatin versus low-dose 5-fluorouracil/cisplatin/Interferon beta
    Ueda, H.
    Tanaka, H.
    Kida, Y.
    Fukuchi, H.
    Ichinose, M.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [15] Low-dose trimetrexate glucuronate and protracted 5-fluorouracil infusion in previously untreated patients with advanced pancreatic cancer
    Amado, RG
    Rosen, LS
    Hecht, JR
    Lin, LS
    Rosen, PJ
    ANNALS OF ONCOLOGY, 2002, 13 (04) : 582 - 588
  • [16] 5-FLUOROURACIL INFUSION AND LOW-DOSE WEEKLY CISPLATIN - AN ANALYSIS OF INCREASED TOXICITY
    JESKE, J
    HANSEN, RM
    LIBNOCH, JA
    ANDERSON, T
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1990, 13 (06): : 485 - 488
  • [17] Hepatic Arterial Infusion Chemotherapy Using Low-Dose 5-Fluorouracil and Cisplatin for Advanced Hepatocellular Carcinoma
    Ueshima, Kazuomi
    Kudo, Masatoshi
    Takita, Masahiro
    Nagai, Tomoyuki
    Tatsumi, Chie
    Ueda, Taisuke
    Kitai, Satoshi
    Ishikawa, Emi
    Yada, Norihisa
    Inoue, Tatsuo
    Hagiwara, Satoru
    Minami, Yasunori
    Chung, Hobyung
    ONCOLOGY, 2010, 78 : 148 - 153
  • [18] Effects of Intermittent 5-Fluorouracil and Low-dose Cisplatin Therapy on Advanced and Recurrent Gastric Cancer
    Kanetaka, Kengo
    Enjoji, Akihito
    Furui, Junichiro
    Nagata, Yasuhiro
    Fujioka, Hikaru
    Shiogama, Toshiaki
    Miyata, Akimi
    Kishikawa, Hiroki
    Matsuo, Shigetoshi
    Iwata, Toru
    Kanematsu, Takashi
    Eguchi, Susumu
    ANTICANCER RESEARCH, 2012, 32 (08) : 3495 - 3499
  • [19] Efficacy of chemoradiotherapy with low-dose cisplatin and continuous infusion of 5-fluorouracil for unresectable squamous cell carcinoma of the esophagus
    Takagawa, Ryo
    Kunisaki, Chikara
    Makino, Hirochika
    Kosaka, Takashi
    Ono, Hidetaka A.
    Akiyama, Hirotoshi
    Shimada, Hiroshi
    DISEASES OF THE ESOPHAGUS, 2009, 22 (06) : 482 - 489
  • [20] Arterial infusion therapy with low-dose cisplatin and continuous 5-fluorouracil for isolated hepatic recurrence of gastric carcinoma
    Akamo Y.
    Takeyama H.
    Mohri N.
    Teranishi F.
    Manabe T.
    International Journal of Clinical Oncology, 2000, 5 (3) : 192 - 194
12345