Expression of c-fos in the rat brainstem after chronic intermittent hypoxia

被引：86
|
作者：
Greenberg, HE [1 ]
Sica, AL
Scharf, SM
Ruggiero, DA
机构：
[1] Long Isl Jewish Med Ctr, Div Pulm & Crit Care Med, New Hyde Park, NY 11040 USA
[2] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
[3] Columbia Univ Coll Phys & Surg, Dept Anat & Cell Biol, New York, NY 10032 USA
[4] Neurol Res Inst Lubec, Lubec, ME 04652 USA
来源：
BRAIN RESEARCH | 1999年 / 816卷 / 02期
基金：
美国国家卫生研究院;
关键词：
intermittent hypoxia c-fos; sympathetic nervous system; obstructive sleep apnea;
D O I：
10.1016/S0006-8993(98)01222-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Chronic intermittent hypoxia(CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CM alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fas labeling was seen in the nucleus of the solitary tract and ventrolateral medulla as well as other brainstem regions involved in regulation of SND. Increased expression of c-fas after CIH may indicate changes in neuronal genetic transcription which ultimately modulate SND. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：638 / 645
页数：8
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