Drug-Loaded Chondroitin Sulfate Microspheres Generated from Microfluidic Electrospray for Wound Healing

被引：12
|
作者：
Zhang, Hongzhen [1 ]
Xu, Ronghua [1 ]
Yin, Zuowen [1 ]
Yu, Jun [1 ]
Liang, Ning [2 ]
Geng, Qian [3 ]
机构：
[1] Huazhong Univ Sci & Technol, Gastrointestinal Surg, Union Shenzhen Hosp, Shenzhen 518052, Peoples R China
[2] Nanjing Med Univ, Dept Dermatol, Affiliated Changzhou Peoples Hosp 2, Changzhou 213000, Peoples R China
[3] Huazhong Univ Sci & Technol, Emergency Dept, Union Shenzhen Hosp, Shenzhen 518052, Peoples R China
来源：
MACROMOLECULAR RESEARCH | 2022年 / 30卷 / 01期
关键词：
drug-loading; chondroitin sulfate; microspheres; microfluidic electrospray; wound healing; HYDROGEL; SCAFFOLDS; DELIVERY; RELEASE; ACID;
D O I：
10.1007/s13233-022-0001-4
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Wound treatment is an important issue and poses a critical challenge for healthcare systems. It is of great significance to develop materials for wound repair and regeneration. Herein, we presented a kind of novel drug-loaded methacryloyl chondroitin sulfate (CSMA) microspheres for promoting the wound healing process. The CSMA droplets were generated from microfluidic electrospray and polymerized with ultraviolet light. With further freeze-drying and drug uploading, the drug-loaded CSMA microspheres were achieved. The prepared microspheres exhibited excellent biocompatibility, and the following animal experiments indicated they could promote wound healing significantly. This study opens the door to drug-loaded CSMA microspheres for wound healing applications.
引用
收藏
页码：36 / 42
页数：7
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