PGC-1α, glucose metabolism and type 2 diabetes mellitus

被引：123

作者：

Wu, Haijiang ^{[1
,2
]}

Deng, Xinna ^{[3
,4
]}

Shi, Yonghong ^{[1
,2
]}

Su, Ye ^{[5
,6
,7
]}

Wei, Jinying ^{[1
,2
]}

Duan, Huijun ^{[1
,2
]}

机构：

[1] Hebei Med Univ, Dept Pathol, Shijiazhuang, Peoples R China

[2] Key Lab Kidney Dis Hebei Prov, Shijiazhuang, Peoples R China

[3] Hebei Gen Hosp, Dept Oncol, Shijiazhuang, Peoples R China

[4] Hebei Gen Hosp, Dept Immunotherapy, Shijiazhuang, Peoples R China

[5] London Hlth Sci Ctr, Lawson Hlth Res Inst, Mathew Mailing Ctr Translat Transplantat Studies, London, ON, Canada

[6] Univ Western Ontario, Dept Med, London, ON, Canada

[7] Univ Western Ontario, Dept Pathol, London, ON, Canada

来源：

JOURNAL OF ENDOCRINOLOGY | 2016年 / 229卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PGC-1; alpha; type 2 diabetes mellitus; glucose metabolism; polymorphism; ACTIVATED-RECEPTOR-GAMMA; HEPATOCYTE NUCLEAR FACTOR-4-ALPHA; REGULATES HEPATIC GLUCONEOGENESIS; COACTIVATOR 1-ALPHA PGC-1-ALPHA; LIPOGENIC GENE-EXPRESSION; C VIRUS-INFECTION; SKELETAL-MUSCLE; INSULIN-RESISTANCE; PROTEIN-KINASE; PPAR-GAMMA;

D O I：

10.1530/JOE-16-0021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by glucose metabolic disturbance. A number of transcription factors and coactivators are involved in this process. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1 alpha is involved in the regulation of T2DM. Therefore, a better understanding of the roles of PGC-1 alpha may shed light on more efficient therapeutic strategies. Here, we review the most recent progress on PGC-1 alpha and discuss its regulatory network in major glucose metabolic tissues such as the liver, skeletal muscle, pancreas and kidney. The significant associations between PGC-1 alpha polymorphisms and T2DM are also discussed in this review.

引用

页码：R99 / R115

页数：17

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