RETRACTED: Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway (Retracted article. See April, 2017)

被引：30
|
作者：
Li, Jun [1 ]
Song, Zhangjun [2 ]
Wang, Yiyu [1 ]
Yin, Yue [1 ]
Liu, Ying [1 ]
Yuan, Rong [1 ]
Nan, Xing [1 ]
机构：
[1] Shaanxi Prov Tumor Hosp, Tumor Res Ctr, 309 YanTa West Rd, Xian 710061, Peoples R China
[2] Shaanxi Prov Tumor Hosp, Breast Surg Ctr, Xian 710061, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 08期
关键词：
Sphingosine kinase 1; Sphingosine-1-phosphate; Triple-negative breast cancer; Chemotherapy; AKT; PI3K; SPHINGOSINE KINASE 1; THERAPEUTIC TARGET; COLON-CANCER; SURVIVAL; 1-PHOSPHATE; EXPRESSION; PROGNOSIS; APOPTOSIS;
D O I：
10.1007/s13277-016-4954-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sphingosine kinase 1 (SphK1) expression is elevated in various cancers and is associated with shorter survival times for patients. However, the molecular mechanism of SphK1 up-regulation in triple-negative breast cancer (TNBC) remains unclear. In this study, we assayed the expression level of SphK1 in TNBC tissues by qRT-PCR and immunohistochemistry. The level of S1P was quantified by ELISA in the serum of TNBC patients. Our results found that the levels of SphK1 and S1P were significantly increased in TNBC patients compared with normal control. Furthermore, knockdown of SphK1 with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion. These data suggest that SphK1 has an important role in TNBC and presents an attractive therapeutic target for the treatment for TNBC.
引用
收藏
页码：10587 / 10593
页数：7
相关论文
共 50 条
  • [31] MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer
    Xu, J-H
    Zhao, J-X
    Jiang, M-Y
    Yang, L-P
    Sun, M-L
    Wang, H-W
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (06) : 3122 - 3129
  • [32] RETRACTED: Research Progress of PI3K/PTEN/AKT Signaling Pathway Associated with Renal Cell Carcinoma (Retracted Article)
    Fang, Yakun
    Ji, Wenjun
    Yan, Chao
    DISEASE MARKERS, 2022, 2022
  • [33] MEX3A promotes triple negative breast cancer proliferation and migration via the PI3K/AKT signaling pathway
    Jiang, Shujun
    Meng, Lingjia
    Chen, Xinye
    Liu, Hongmei
    Zhang, Junfeng
    Chen, Fei
    Zheng, Jie
    Liu, Hui
    Wang, Feng
    Hu, Junyan
    Li, Zhe
    EXPERIMENTAL CELL RESEARCH, 2020, 395 (02)
  • [34] RETRACTED: PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway (Retracted Article)
    Yang, Jianyi
    Gong, Xuejun
    Ouyang, Lu
    He, Wen
    Xiao, Rou
    Tan, Li
    ONCOLOGY LETTERS, 2016, 12 (02) : 1139 - 1143
  • [35] RETRACTED: FOXK1 promotes malignant progression of breast cancer by activating PI3K/AKT/mTOR signaling pathway (Retracted article. See vol. 25, pg. 2159, 2021)
    Li, Z. -Q.
    Qu, M.
    Wan, H. -X.
    Wang, H.
    Deng, Q.
    Zhang, Y.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (22) : 9978 - 9987
  • [36] RETRACTED: Axl as a downstream effector of TGF-β1 via PI3K/Akt-PAK1 signaling pathway promotes tumor invasion and chemoresistance in breast carcinoma (Retracted Article)
    Li, Yanyan
    Jia, Li
    Liu, Chen
    Gong, Yanxin
    Ren, Dongliang
    Wang, Ning
    Zhang, Xu
    Zhao, Yongfu
    TUMOR BIOLOGY, 2015, 36 (02) : 1115 - 1127
  • [37] RETRACTED: Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer (Retracted Article)
    Liu, Tao
    Liang, Xiangsen
    Sun, Yu
    Yang, Shengzhuang
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021, 22 (04)
  • [38] RETRACTED: GATA1 gene silencing inhibits invasion, proliferation and migration of cholangiocarcinoma stem cells via disrupting the PI3K/AKT pathway (Retracted Article)
    Shi, Guang
    Zhang, Hong
    Yu, Qiong
    Hu, Chunmei
    Ji, Youbo
    ONCOTARGETS AND THERAPY, 2019, 12 : 5335 - 5354
  • [39] RETRACTED: CIP2A mediates prostate cancer progression via the c-Myc signaling pathway (Retracted article. See April, 2017)
    Guo, Zexiong
    Liu, Dehao
    Su, Zexuan
    TUMOR BIOLOGY, 2015, 36 (06) : 4777 - 4783
  • [40] RETRACTED: Promethazine inhibits neuronal apoptosis via PI3K/Akt signaling pathway in rats with cerebral infarction (Retracted Article)
    Pan, X-D.
    Chen, X-L.
    Ding, S-F.
    Kou, D.
    Hu, H-L.
    Li, L.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 : 126 - 134
12345