Synthesis and structural insights of novel 2-diethylamino-6-methyl-4(3H)-pyrimidinones

被引：0
|
作者：
Craciun, L [1 ]
Kovacs, D [1 ]
Craciun, R [1 ]
Mager, S [1 ]
机构：
[1] Univ Babes Bolyai, Dept Organ Chem, R-3400 Cluj Napoca, Romania
来源：
HETEROCYCLIC COMMUNICATIONS | 1998年 / 4卷 / 02期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of three previously unknown 2-diethylamino-6-methyl-4(3H)-pyrimidinones via the condensation reaction of ethyl 2-alkylacetoacetates with N,N-diethylguanidine is described. The reported compounds, 5-ethyl- (1) under bar, 5-n-propyl-(2) under bar, and 5-n-butyl-2-diethylamino-6-methyl-4(3H)-pyrimidinone (3) under bar, were characterized by H-1 and C-13 NMR, IR, UV and mass spectrometry, and their tautomerism is discussed and compared with literature data for similar compounds. The results of NOE experiments suggest that in solution (1) under bar (2) under bar and (3) under bar, exist predominantly as the 4(3H)-lactam tautomers (N3).
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页码：157 / 162
页数：6
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