Asymmetric synthesis of optically active 1,3-oxathiolane nucleoside analogues

被引：4

作者：

Caputo, R ^{[1
]}

Guaragna, A ^{[1
]}

Palumbo, G ^{[1
]}

Pedatella, S ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Organ & Biol Chem, I-80134 Naples, Italy

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1998年 / 17卷 / 9-11期

关键词：

D O I：

10.1080/07328319808004709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A ready asymmetric synthesis of 3'-oxa-4'-thionucleosides has been accomplished in three main steps from benzoyloxyethanal. The synthesis is characterized by high overall yield and appreciable enantiomeric excesses. It represents a general synthetic scheme to prepare a wide range of heterosubstituted sulfur-containing nucleoside analogues.

引用

页码：1739 / 1745

页数：7

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