Asymmetric synthesis of optically active 1,3-oxathiolane nucleoside analogues

被引：4
|
作者：
Caputo, R [1 ]
Guaragna, A [1 ]
Palumbo, G [1 ]
Pedatella, S [1 ]
机构：
[1] Univ Naples Federico II, Dept Organ & Biol Chem, I-80134 Naples, Italy
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1998年 / 17卷 / 9-11期
关键词：
D O I：
10.1080/07328319808004709
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A ready asymmetric synthesis of 3'-oxa-4'-thionucleosides has been accomplished in three main steps from benzoyloxyethanal. The synthesis is characterized by high overall yield and appreciable enantiomeric excesses. It represents a general synthetic scheme to prepare a wide range of heterosubstituted sulfur-containing nucleoside analogues.
引用
收藏
页码：1739 / 1745
页数：7
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