Line Scan Spatial Speckle Contrast Imaging and Its Application in Blood Flow Imaging

被引:5
|
作者
Du, E. [1 ]
Shen, Shuhao [2 ]
Qiu, Anqi [2 ]
Chen, Nanguang [2 ,3 ]
机构
[1] Shenzhen Inst Informat Technol, Sch Microelect, Shenzhen 518172, Peoples R China
[2] Natl Univ Singapore, Dept Biomed Engn, 7 Engn Dr 1, Singapore 117574, Singapore
[3] NUS Suzhou Res Inst, 377 Linquan St,Ind Pk, Suzhou 215128, Peoples R China
来源
APPLIED SCIENCES-BASEL | 2021年 / 11卷 / 22期
关键词
laser speckle; line-scan; cardiac; blood flow; confocal; chick embryo; VISUALIZATION; FLOWMETRY; VELOCITY; SKULL;
D O I
10.3390/app112210969
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Laser speckle imaging has been an indispensable tool for visualizing blood flow in biomedical applications. We proposed a novel design of the laser speckle imaging system, which combines confocal illumination and detection with various speckle analysis methods. The system can be operated by three imaging modes. One is surface illumination laser speckle contrast imaging (SI-LSCI) and the other two are line scan temporal speckle contrast imaging (LS-TSCI) and line scan spatial speckle contrast imaging (LS-SSCI). The experimental results of flow phantoms have validated the mixture model, which combines the Lorentzian and Gaussian models to describe the simultaneous existence of both Brownian motions and ordered flow. Our experimental results of in vivo chick embryos demonstrate that LS-SSCI maintains high temporal resolution and is less affected by motion artifacts. LS-SSCI can provide better image quality for in vivo imaging blood chick embryos than LS-TSCI. Furthermore, the experiential results present that LS-SSCI can detect and quantify the blood flow change during vascular clipping, and shows great potential in diagnosing vascular diseases, such as angiosclerosis, angiostenosis, or angiemphraxis.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Continuous Blood Flow Visualization with Laser Speckle Contrast Imaging During Cerebrovascular Surgery
    Ashour, Ramsey
    Miller, David
    Sullender, Colin
    Dunn, Andrew
    JOURNAL OF NEUROSURGERY, 2022, 136 (05)
  • [42] Laser speckle contrast imaging of collateral blood flow during acute ischemic stroke
    Armitage, Glenn A.
    Todd, Kathryn G.
    Shuaib, Ashfaq
    Winship, Ian R.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2010, 30 (08): : 1432 - 1436
  • [43] Increased blood flow in keloids and adjacent skin revealed by laser speckle contrast imaging
    Liu, Qingliang
    Wang, Xiaojun
    Jia, Yihong
    Long, Xiao
    Yu, Nanze
    Wang, Youbin
    Chen, Bo
    LASERS IN SURGERY AND MEDICINE, 2016, 48 (04) : 360 - 364
  • [44] Application of laser speckle contrast imaging in laparoscopic surgery
    Heeman, Wido
    Dijkstra, Klaas
    Hoff, Christiaan
    Koopal, Sietze
    Pierie, Jean-Pierre
    Bouma, Hessel
    Boerma, E. Christiaan
    BIOMEDICAL OPTICS EXPRESS, 2019, 10 (04): : 2010 - 2019
  • [45] Cerebral blood flow patterns induced by photoactivation based on laser speckle contrast imaging
    Zhu, Xuan
    Shi, Liang
    Li, Pengcheng
    Lu, Jinling
    BIOMEDICAL OPTICS EXPRESS, 2024, 15 (12): : 6739 - 6755
  • [46] Laser speckle imaging of blood flow in microcirculation
    Cheng, HY
    Luo, QM
    Liu, Q
    Lu, QA
    Gong, H
    Zeng, SQ
    PHYSICS IN MEDICINE AND BIOLOGY, 2004, 49 (07): : 1347 - 1357
  • [47] Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging
    Cheng, Haiying
    Yan, Yumei
    Duong, Timothy Q.
    OPTICS EXPRESS, 2008, 16 (14): : 10214 - 10219
  • [48] HANDHELD LASER SPECKLE IMAGING SYSTEM FOR NEONATAL BLOOD FLOW IMAGING
    Farraro, Ryan
    Fathi, Omid
    Choi, Bernard
    LASERS IN SURGERY AND MEDICINE, 2015, 47 : 9 - 10
  • [49] Spatial and temporal localisation of the postmortem cerebral blood microcirculation revealed by laser speckle contrast imaging
    Sdobnov, Anton
    Kalchenko, Vyacheslav
    Piavchenko, Gennadii
    Bykov, Alexander
    Meglinski, Igor
    JOURNAL OF VASCULAR RESEARCH, 2023, 60 (SUPP1) : 9 - 9
  • [50] Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortex
    Luo, Zhongchi
    Wang, Zhenguo
    Yuan, Zhijia
    Dua, Congwu
    Pan, Yingtian
    OPTICS LETTERS, 2008, 33 (10) : 1156 - 1158