Archived dengue serum samples produced false-positive results in SARS-CoV-2 lateral flow-based rapid antibody tests

被引:28
|
作者
Nath, Himadri [1 ]
Mallick, Abinash [1 ]
Roy, Subrata [1 ]
Sukla, Soumi [2 ]
Basu, Keya [3 ,4 ]
De, Abhishek [5 ]
Biswas, Subhajit [1 ]
机构
[1] CSIR Indian Inst Chem Biol CSIR IICB, Infect Dis & Immunol Div, 4 Raja SC Mullick Rd, Kolkata 700032, W Bengal, India
[2] Natl Inst Pharmaceut Educ & Res, 168 Maniktala Main Rd, Kolkata 700054, W Bengal, India
[3] Inst Postgrad Med Educ & Res IPGMER, Dept Pathol, 244 Acharya Jagadish Chandra Bose Rd, Kolkata 700020, W Bengal, India
[4] Seth Sukhlal Karnani Mem SSKM Hosp, 244 Acharya Jagadish Chandra Bose Rd, Kolkata 700020, W Bengal, India
[5] Calcutta Natl Med Coll & Hosp, Dept Dermatol, Kolkata 700014, W Bengal, India
关键词
dengue virus; SARS-CoV-2; COVID-19; false-positive; antibody test; cross-reactive; strip test;
D O I
10.1099/jmm.0.001369
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Co-endemicity of SARS-CoV-2 and dengue virus (DV) infection is becoming a matter of serious concern as it has been already reported that antibodies (Ab) elicited by SARS-CoV-2 infection can produce false-positive results in dengue IgG and IgM rapid tests and vice versa. Here we communicate that five of thirteen DV antibody-positive serum samples from Kolkata, archived in 2017 (predating the COVID-19 outbreak), produced false-positive results in SARS-CoV-2 IgG/IgM lateral flow-based rapid tests. Our results emphasize the importance of implementing tests with higher specificity to conduct sero-surveillance for accurate estimation of SARS-CoV-2/DV prevalence in regions where both viruses now co-exist.
引用
收藏
页数:5
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