Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury

被引：26
|
作者：
Li, Zhi [1 ]
Zhao, Wei [1 ]
Liu, Wei [2 ]
Zhou, Ye [2 ]
Jia, Jingqiao [3 ]
Yang, Lifeng [1 ]
机构：
[1] Shenyang Med Coll, Affiliated Cent Hosp, Dept Orthoped, Shenyang 110024, Liaoning, Peoples R China
[2] Shenyang Med Coll, Affiliated Cent Hosp, Dept Obstet, Shenyang 110024, Liaoning, Peoples R China
[3] Liaoning Prov Wellcare Stem Cells Biotechnol Co L, Benxi, Liaoning, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 24期
关键词：
nerve regeneration; stem cells; placenta-derived mesenchymal stem cells; spinal cord injury; neural stem cells; nerve-like cells; motor function; sensory function; neural regeneration; AMNIOTIC MEMBRANE; REPAIR;
D O I：
10.4103/1673-5374.147953
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.
引用
收藏
页码：2197 / 2204
页数：8
相关论文
共 50 条
  • [21] Human placenta-derived cells have mesenchymal stem/progenitor cell potential
    Fukuchi, Y
    Nakajima, H
    Sugiyama, D
    Hirose, I
    Kitamura, T
    Tsuji, K
    STEM CELLS, 2004, 22 (05) : 649 - 658
  • [22] Phenotypic Analysis of Human Placenta-Derived Mesenchymal Stem Cells
    Chen, Ying-Hui A.
    Lin, Abby H. C.
    Liu, Chi-Mou
    Chang, Chiung-Hsin
    Yu, Chen-Hsiang
    Huang, Lynn L. H.
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2017, 7 (03) : 188 - 202
  • [23] Stepwise combined cell transplantation using mesenchymal stem cells and induced pluripotent stem cell-derived motor neuron progenitor cells in spinal cord injury
    Kim, Jang-Woon
    Kim, Juryun
    Mo, Hyunkyung
    Han, Heeju
    Rim, Yeri Alice
    Ju, Ji Hyeon
    STEM CELL RESEARCH & THERAPY, 2024, 15 (01)
  • [24] Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: A pilot study
    Jiang R.
    Han Z.
    Zhuo G.
    Qu X.
    Li X.
    Wang X.
    Shao Y.
    Yang S.
    Han Z.C.
    Frontiers of Medicine, 2011, 5 (1) : 94 - 100
  • [25] Transplantation of neural stem cells into the spinal cord after injury
    Okano, H
    Ogawa, Y
    Nakamura, M
    Kaneko, S
    Iwanami, A
    Toyama, Y
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2003, 14 (03) : 191 - 198
  • [26] Bone Mesenchymal Stem Cells Transplantation and Exercise-induced Spinal Cord Injury
    Xie Jun
    Liu Ruilian
    PROCEEDINGS OF THE 2012 INTERNATIONAL SYMPOSIUM - SPORTS INNOVATION AND DEVELOPMENT OF UNIVERSITIES AND COLLEGES, 2012, : 247 - 251
  • [27] Treatment of spinal cord injury by neural stem cell transplantation
    Nakashima, Kinichi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015, 128 (03) : S40 - S40
  • [28] Neural stem cell transplantation in the repair of spinal cord injury
    Iannotti, C
    Lü, XB
    Lu, PH
    Xu, XM
    PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, 2001, 11 (07) : 490 - +
  • [29] Neural stem cell transplantation in the repair of spinal cord injury
    Christopher IANNOTTI
    吕晓斌
    陆佩华
    徐晓明
    Progress in Natural Science, 2001, (07) : 12 - 24+83-84
  • [30] Characterization of placenta-derived mesenchymal stem cells cultured in autologous human cord blood serum
    Wang, Libin
    Yang, Yinxue
    Zhu, Yongzhao
    Ma, Xiaona
    Liu, Ting
    Zhang, Guangyi
    Fan, Heng
    Ma, Lijun
    Jin, Yiran
    Yan, Xiurui
    Wei, Jun
    Li, Yukui
    MOLECULAR MEDICINE REPORTS, 2012, 6 (04) : 760 - 766
12345