Pembrolizumab combined with neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy followed surgery for locally advanced esophageal squamous cell carcinoma: Protocol for a multi-center, prospective, randomized-controlled, phase III clinical study (Keystone-002)

被引:0
|
作者
Jiang, H. [1 ]
Shang, X. [1 ]
Zhang, C. [1 ]
Yue, J. [1 ]
Duan, X. [1 ]
Ma, Z. [1 ]
Chen, C. [1 ]
Zhang, W. [1 ,2 ]
Pang, Q. [1 ]
Zhang, W. [1 ,2 ]
Liu, L. [2 ]
Ren, X. [2 ]
Meng, B. [3 ]
Zhao, G. [3 ]
Zhang, P. [4 ]
Wei, Y. [5 ]
Ma, Y. [6 ]
Zhang, L. [7 ]
Li, Y. [8 ]
机构
[1] Tianjin Med Univ, Canc Inst & Hosp, Dept Minimally Invas Esophageal Surg, Tianjin, Peoples R China
[2] Tianjin Med Univ, Canc Inst & Hosp, Dept Immunol, Tianjin, Peoples R China
[3] Tianjin Med Univ, Canc Inst & Hosp, Dept Pathol, Tianjin, Peoples R China
[4] Tianjin Med Univ, Gen Hosp, Dept Thorac Surg, Tianjin, Peoples R China
[5] Qingdao Univ, Affiliated Hosp, Dept Thorac Surg, Qingdao, Peoples R China
[6] Liaoning Canc Hosp, Dept Thorac Surg, Shenyang, Peoples R China
[7] Shandong First Med Univ, Shandong Prov Hosp, Dept Thorac Surg, Jinan, Peoples R China
[8] Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Canc Hosp, Dept Thorac Surg Oncol, Beijing, Peoples R China
关键词
D O I
10.1016/j.annonc.2021.10.185
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
166TiP
引用
收藏
页码:S1454 / S1455
页数:2
相关论文
共 50 条
  • [41] A prospective phase II randomized study of docetaxel combined with lobaplatin versus TPF regimen induction chemotherapy followed by concurrent chemoradiotherapy for locally advanced head and neck squamous cell carcinoma
    Mang Zhang
    Yu Chen
    Weili Wu
    Feng Jin
    Yuanyuan Li
    Jinhua Long
    Xiuling Luo
    Xiuyun Gong
    Xiaoxiao Chen
    Lina Liu
    Hong Tang
    Ziqi Wang
    Journal of Cancer Research and Clinical Oncology, 2023, 149 : 18081 - 18091
  • [42] A phase III study on neoadjuvant chemotherapy versus neoadjuvant toripalimab plus chemotherapy for locally advanced esophageal squamous cell carcinoma: Henan Cancer Hospital Thoracic Oncology Group 1909 (HCHTOG1909)
    Zheng, Yan
    Liu, Xian-Ben
    Sun, Hai-Bo
    Xu, Jinliang
    Shen, Sining
    Ba, Yu-Feng
    Yan, Ming
    Qin, Zimin
    Liu, Bao-Xing
    Wang, Zong-Fei
    Liu, Shi-Lei
    Zhang, Rui-Xiang
    Chen, Pei-Nan
    Liang, Guang-Hui
    Yuan, Dongfeng
    Li, Zhen-Xuan
    Liu, Qi
    Wang, Hao-Ran
    Li, Hao-Miao
    Lv, Hongwei
    Ma, Xiaochao
    Zhu, Jianping
    Yu, Yong-Kui
    Xing, Wen-Qun
    ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (01)
  • [43] Preliminary results from the multicenter, randomized phase III trial (SCIENCE): Comparing chemotherapy plus sintilimab and chemoradiotherapy plus sintilimab versus chemoradiotherapy for neoadjuvant treatment in resectable locally advanced esophageal squamous cell carcinoma.
    Leng, Xuefeng
    He, Wenwu
    Lyu, Jiahua
    Gong, Lei
    Hu, Tongchen
    Zhou, Haining
    Peng, Lin
    Liu, Guangyuan
    Wang, Kangning
    Fang, Qiang
    Qi, Yunxiang
    Zhou, Yehan
    Zhang, Wencheng
    Tang, Peng
    Li, Tao
    Han, Yongtao
    JOURNAL OF CLINICAL ONCOLOGY, 2025, 43 (4_SUPPL) : LBA329 - LBA329
  • [45] Neoadjuvant camrelizumab followed by concurrent camrelizumab plus chemotherapy for locally advanced esophageal squamous cell carcinoma: a single-arm, phase II study
    Sheng, Yinliang
    Meng, Xiangrui
    Zhang, Chunyang
    Shan, Zhengzheng
    Li, Feng
    Wu, Bin
    Xu, Mengli
    Li, Aijia
    Guan, Lulu
    Chen, Lidong
    Sun, Shuzhen
    Ma, Yihui
    Lu, Taiying
    Zhao, Song
    Fan, Qingxia
    Qi, Yu
    Wang, Feng
    JOURNAL OF THORACIC DISEASE, 2024, 16 (08) : 5337 - 5347
  • [46] Safety and efficacy of camrelizumab combined with radiotherapy as neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma: a prospective single-arm phase II clinical trial protocol
    Maohui Chen
    Yizhou Huang
    Shuliang Zhang
    Taidui Zeng
    Guanglei Huang
    Chun Chen
    Bin Zheng
    Trials, 24 (1)
  • [47] Safety and efficacy of camrelizumab combined with radiotherapy as neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma: a prospective single-arm phase II clinical trial protocol
    Chen, Maohui
    Huang, Yizhou
    Zhang, Shuliang
    Zeng, Taidui
    Huang, Guanglei
    Chen, Chun
    Zheng, Bin
    TRIALS, 2023, 24 (01)
  • [48] Two cycles versus four cycles of neoadjuvant camrelizumab plus chemotherapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC): A prospective, multicenter and randomized study.
    Zhang, Qin
    Cao, Guochun
    Fan, Zhaohui
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 : 350 - 350
  • [49] Safety and efficacy of pembrolizumab combined with paclitaxel and cisplatin as a neoadjuvant treatment for locally advanced resectable (stage III) esophageal squamous cell carcinoma (Keystone-001): Interim analysis of a prospective, single-arm, single-center, phase II trial
    Shang, X.
    Zhang, C.
    Zhao, G.
    Zhang, W.
    Liu, L.
    Duan, X.
    Yue, J.
    Ma, Z.
    Chen, C.
    Meng, B.
    Ren, X.
    Jiang, H.
    ANNALS OF ONCOLOGY, 2021, 32 : S1428 - S1429
  • [50] A randomized, controlled, multicenter study of nabpaclitaxel plus cisplatin followed by surgery versus surgery alone for locally advanced esophageal squamous cell carcinoma (ESCC)
    Liu, Junfeng
    Wang, Yan
    Cao, Bingji
    Zhang, Shaowei
    Cao, Fumin
    Gao, Liping
    Sun, Nan
    Ma, Yuquan
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (04)