Exact Mediation Analysis for Ordinal Outcome and Binary Mediator

被引:2
|
作者
Stanghellini, Elena [1 ]
Kateri, Maria [2 ]
机构
[1] Univ Perugia, Dept Econ, Via Pascoli 1, I-06100 Perugia, Italy
[2] Rhein Westfal TH Aachen, Inst Stat, Aachen, Germany
关键词
Binary mediator; Causal effects; Mediation; Natural effect model; Ordinal outcome;
D O I
10.1097/EDE.0000000000001540
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
With reference to a single mediator context, this brief report presents a model-based strategy to estimate counterfactual direct and indirect effects when the response variable is ordinal and the mediator is binary. Postulating a logistic regression model for the mediator and a cumulative logit model for the outcome, we present the exact parametric formulation of the causal effects, thereby extending previous work that only contained approximated results. The identification conditions are equivalent to the ones already established in the literature. The effects can be estimated by making use of standard statistical software and standard errors can be computed via a bootstrap algorithm. To make the methodology accessible, routines to implement the proposal in R are presented in the eAppendix; http://links.www.com/EDE/B962. We also derive the natural effect model coherent with the postulated data-generating mechanism.
引用
收藏
页码:840 / 842
页数:3
相关论文
共 50 条
  • [41] Parametric-Regression-Based Causal Mediation Analysis of Binary Outcomes and Binary Mediators: Moving Beyond the Rareness or Commonness of the Outcome
    Samoilenko, Mariia
    Lefebvre, Genevieve
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 2021, 190 (09) : 1846 - 1858
  • [42] EXACT ANALYSIS FOR PAIRED BINARY DATA
    HIRJI, KF
    BIOMETRICS, 1994, 50 (04) : 964 - 974
  • [43] Exact confidence intervals for the average causal effect on a binary outcome
    Li, Xinran
    Ding, Peng
    STATISTICS IN MEDICINE, 2016, 35 (06) : 957 - 960
  • [44] A shift algorithm for exact computation in sequential tests with binary outcome
    Högel, J
    BIOMETRICAL JOURNAL, 2000, 42 (02) : 189 - 196
  • [45] On Causal Mediation Analysis with a Survival Outcome
    Tchetgen, Eric J. Tchetgen
    INTERNATIONAL JOURNAL OF BIOSTATISTICS, 2011, 7 (01):
  • [46] Statistical Practice of Ordinal Outcome Analysis in Neurologic Trials
    Long, Yongxi
    de Ruiter, Sophie C.
    Luijten, Linda W. G.
    Wiegers, Eveline J. A.
    Dippel, Diederik W. J.
    Van Doorn, Pieter A.
    Jacobs, Bart C.
    Steyerberg, Ewout W.
    NEUROLOGY, 2025, 104 (04)
  • [47] The Implications of Using Binary Outcomes in Mediation Analysis
    Lee, Hopin
    Hubscher, Markus
    McAuley, James H.
    JOURNAL OF PAIN, 2016, 17 (09): : 1045 - 1046
  • [48] Causal mediation analysis with mediator values below an assay limit
    Chernofsky, Ariel
    Bosch, Ronald J.
    Lok, Judith J.
    STATISTICS IN MEDICINE, 2024, 43 (12) : 2299 - 2313
  • [49] Mediation Analysis with Random Distribution as Mediator with an Application to iCOMPARE Trial
    Jingru Zhang
    Mathias Basner
    Christopher W. Jones
    David F. Dinges
    Haochang Shou
    Hongzhe Li
    Statistics in Biosciences, 2024, 16 : 107 - 128
  • [50] Mediation Analysis with Random Distribution as Mediator with an Application to iCOMPARE Trial
    Zhang, Jingru
    Basner, Mathias
    Jones, Christopher W.
    Dinges, David F.
    Shou, Haochang
    Li, Hongzhe
    STATISTICS IN BIOSCIENCES, 2024, 16 (01) : 107 - 128