Autoinflammation and HLA-B27: Beyond Antigen Presentation

被引：13
|
作者：
Sibley, Cailin H. [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Med, Div Arthrit & Rheumat Dis, 3181 SW Sam Jackson Pk Rd OP 09, Portland, OR 97239 USA
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2016年 / 24卷 / 04期
关键词：
Autoinflammation; HLA-B27; IL-1; innate; spondyloarthritis; UNFOLDED PROTEIN RESPONSE; ACTIVE ANKYLOSING-SPONDYLITIS; ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; GENOME-WIDE ASSOCIATION; TUMOR-NECROSIS-FACTOR; PSORIATIC-ARTHRITIS; TRANSGENIC RATS; INFLAMMATORY DISEASE; REACTIVE ARTHRITIS; DOUBLE-BLIND;
D O I：
10.1080/09273948.2016.1175641
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
HLA-B27 associated disorders comprise a group of inflammatory conditions which have in common an association with the HLA class I molecule, HLA-B27. Given this association, these diseases are classically considered disorders of adaptive immunity. However, mounting data are challenging this assumption and confirming that innate immunity plays a more prominent role in pathogenesis than previously suspected. In this review, the concept of autoinflammation is discussed and evidence is presented from human and animal models to support a key role for innate immunity in HLA-B27 associated disorders.
引用
收藏
页码：460 / 469
页数：10
相关论文
共 50 条
  • [41] TYPING OF SERUM-SOLUBLE HLA-B27 ANTIGEN BY ELISA
    POULETTY, P
    CHANG, C
    KALIL, J
    ATWOOD, E
    FERRONE, S
    SHIMIZU, B
    HOWSON, W
    MAZAHERI, R
    DELVILLANO, B
    GRUMET, C
    TISSUE ANTIGENS, 1993, 42 (01): : 14 - 19
  • [42] Clinical Characteristics of Patients with Spondyloarthritides and HLA-B27 Positive Antigen
    Glasnovic, Marija
    Bosnjak, Ivica
    Sram, Miroslav
    Vranjes, Zeljko
    Vcev, Aleksandar
    Dobrosevic, Blazenka
    Petricevic, Jasminka Sincic
    Horvatic, Elizabeta
    Orkic, Zelimir
    Tadzic, Refmir
    Soldo, Anamarija
    Sisljagic, Dina
    Dinjar, Kristijan
    COLLEGIUM ANTROPOLOGICUM, 2011, 35 (02) : 397 - 402
  • [43] Exploring the Pathogenesis of Spondylarthritis beyond HLA-B27: A Descriptive Review
    Nagit, Ruxandra-Elena
    Rezus, Elena
    Cianga, Petru
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (11)
  • [44] Association between HLA-B27 antigen with chronic synovitis in hemophilia
    Hansen, K.
    Heisel, M.
    Reding, M.
    Chan, R.
    Truelson, M.
    HAEMOPHILIA, 2009, 15 (02) : 631 - 631
  • [45] Prevalence of HLA-B27 and subtypes of HLA-B27 associated with ankylosing spondylitis in Galicia, Spain
    Fernández-Sueiro, JL
    Alonsol, C
    Blanco, FJ
    Rodríguez-Gómez, M
    Galdo, F
    González-Gay, MA
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2004, 22 (04) : 465 - 468
  • [46] Orbital Inflammatory Disease: Unusual Presentation of Enthesitis in an HLA-B27 Spondyloarthropathy
    Sachdeva, Amrita
    Kramer, Neil
    Rosenstein, Elliot D.
    OCULAR IMMUNOLOGY AND INFLAMMATION, 2012, 20 (06) : 468 - 470
  • [47] HLA-B27 since 1990
    Feltkamp, TEW
    CLINICAL RHEUMATOLOGY, 1996, 15 : 9 - 9
  • [48] HLA-B27 AND AGRANULOCYTOSIS BY LEVAMISOLE
    DIEZ, RA
    IMMUNOLOGY TODAY, 1990, 11 (08): : 270 - 270
  • [49] HLA-B27 MISFOLDING AND SPONDYLOARTHRITIS
    Colbert, R. A.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2014, 32 (05) : 769 - 769
  • [50] Epidemiology of HLA-B27 and arthritis
    Khan, MA
    CLINICAL RHEUMATOLOGY, 1996, 15 : 10 - 12
12345