Laser treatments on skin enhancing and controlling transdermal delivery of 5-fluorouracil

被引:47
|
作者
Gomez, Clara [1 ]
Costela, Angel [1 ]
Garcia-Moreno, Inmaculada [1 ]
Llanes, Felipe [2 ]
Teijon, Jose M. [3 ]
Blanco, Dolores [3 ]
机构
[1] CSIC, Inst Quim Fis Rocasolano, Dept Quim Laser, E-28006 Madrid, Spain
[2] UCM, Fac Med, Dept Anat Patol, Madrid, Spain
[3] UCM, Fac Med, Dept Bioquim & Biol Mol 3, Madrid, Spain
关键词
5-Fu; Nd : YAG laser; transdermal delivery; stratum corneum;
D O I
10.1002/lsm.20590
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background and Objective: Laser ablation of stratum corneum (SC) enhances transdermal delivery of hydrophilic drugs. The influence of the infrared (IR) (lambda = 1,064 nm), visible (lambda = 532 nm), and ultraviolet (UV) (lambda = 355 nm) radiations of a Nd:YAG laser on transdermal delivery of 5-Fluorouracil (5-Fu) across skin was studied in vitro. Materials and Methods: Pinna skin of the inner side of rabbit ear, was used for the skin permeation. The light source for laser treatment was a Q-switched Nd:YAG laser (Lotis TII SL-2132). Ablation thresholds were estimated by using a photoacoustic technique. In addition, permeation study, and morphological and structural skin examination by histology and differential scanning calorimetry (DSC) were carried out. Results: A significant increase in the permeation of 5-Fu across skin pre-treatment with the three different wavelengths studied was obtained. Since irradiation at 1,064 nm allows deep penetration of the radiation, collagen fibers were affected [7.7 J/cm(2) (15 Hz)]. Visible radiation of Nd:YAG laser showed the wider range of fluences (3-8.4 J/cm(2) at 15 Hz) to enhance skin delivery of 5-Fu, without risk of skin lesion. UV radiation required minor energy contribution to produce the same effects within a narrower range of fluences [0.3 J/cm(2) (5 Hz)-1.5 J/cm(2) (15 Hz)] so the process is less controlled and this radiation shows greater impact on the lipidic structure than visible and IR radiations. Conclusions: Use of the visible radiation of a Nd:YAG laser is a good method for improving the efficacy of topical chemotherapy of 5-Fu. Lasers Surg. Med. 40: 6-12, 2008. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码:6 / 12
页数:7
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