Analytical techniques for solid-phase organic and combinatorial synthesis

被引：46
|
作者：
Egner, BJ
Bradley, M
机构：
[1] Department of Chemistry, University of Southampton, Highfield
来源：
DRUG DISCOVERY TODAY | 1997年 / 2卷 / 03期
关键词：
D O I：
10.1016/S1359-6446(97)01003-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the developmental phase leading to solid-phase library generation, it is essential that reactions can be efficiently and readily optimized and quantified, and this requires reliable and sensitive techniques for the analysis of solid-phase reactions. The exploding interest in different types of solid-phase chemistry is placing increased demands on the reliability, diversity and sensitivity of such analytical methods. The authors describe the most exciting developments of the past 4-5 years.
引用
收藏
页码：102 / 109
页数：8
相关论文
共 50 条
  • [31] Solid-phase combinatorial synthesis of aeruginosin derivatives and their biological evaluation
    Doi, Takayuki
    Hoshina, Yoichiro
    Mogi, Hiroyuki
    Yamada, Yoshifumi
    Takahashi, Takashi
    JOURNAL OF COMBINATORIAL CHEMISTRY, 2006, 8 (04): : 571 - 582
  • [32] Synthesis of nucleoside libraries by solid-phase combinatorial strategies.
    An, HY
    Rong, F
    Habib, Q
    Amador, RB
    Ding, Y
    Gunic, E
    Koh, YH
    Chen, HM
    Girardet, JL
    Li, D
    Huang, JF
    Han, XG
    Hong, Z
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U183 - U183
  • [33] Solid-phase synthesis of diketopiperazines, useful scaffolds for combinatorial chemistry
    del Fresno, M
    Alsina, J
    Royo, M
    Barany, G
    Albericio, F
    TETRAHEDRON LETTERS, 1998, 39 (17) : 2639 - 2642
  • [34] SOLID-PHASE SYNTHESIS OF ARYL AND BENZYLPIPERAZINES AND THEIR APPLICATION IN COMBINATORIAL CHEMISTRY
    DANKWARDT, SM
    NEWMAN, SR
    KRSTENANSKY, JL
    TETRAHEDRON LETTERS, 1995, 36 (28) : 4923 - 4926
  • [35] Linear solid phase combinatorial organic synthesis.
    Johnson, CW
    Schwabacher, AW
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U139 - U139
  • [36] Applications of FTIR in solid-phase organic synthesis
    Huang, Q
    Long, Q
    Zheng, BZ
    PROGRESS IN CHEMISTRY, 2005, 17 (05) : 889 - 896
  • [37] The traceless solid-phase synthesis of organic molecules
    Tumelty, D
    Pan, YJ
    Holmes, CP
    COMBINATORIAL CHEMISTRY, PT B, 2003, 369 : 164 - 182
  • [38] Greener solvents for solid-phase organic synthesis
    Lawrenson, Stefan B.
    PURE AND APPLIED CHEMISTRY, 2018, 90 (01) : 157 - 165
  • [39] Protecting groups in solid-phase organic synthesis
    Orain, D
    Ellard, J
    Bradley, M
    JOURNAL OF COMBINATORIAL CHEMISTRY, 2002, 4 (01): : 1 - 16
  • [40] Electrons as a reagent in solid-phase organic synthesis
    Mentel, Matthias
    Breinbauer, Rolf
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007, 2007 (26) : 4283 - 4292
12345