Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer

被引：14

作者：

Masania, Jinit ^{[1
]}

Li, Jiejin ^{[2
]}

Smerdon, Stephen J. ^{[2
]}

Macmillan, Derek ^{[1
]}

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

[2] MRC Natl Inst Med Res, Div Mol Struct, London NW7 1AA, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 22期

基金：

英国医学研究理事会;

关键词：

CHEMOSELECTIVE LIGATION; EXPRESSED PROTEIN; GLYCOPEPTIDE; PEPTIDE; CHEMISTRY; GLYCOSYLATION; STRATEGIES; MECHANISM; LINKAGE; AZIDES;

D O I：

10.1039/c0ob00363h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptide thioesters are important tools for protein synthesis and semi-synthesis through their use in Native Chemical Ligation (NCL). NCL can be employed to assemble site-specifically modified proteins that can help elucidate the mechanisms of biomolecular processes. In this article we explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through N -> S acyl transfer.

引用

页码：5113 / 5119

页数：7

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