Peptoids as endothelin receptor antagonists

被引：6

作者：

Dasgupta, F ^{[1
]}

Gangadhar, N ^{[1
]}

Bruhaspathy, M ^{[1
]}

Verma, AK ^{[1
]}

Sarin, S ^{[1
]}

Mukherjee, AK ^{[1
]}

机构：

[1] Ranbaxy Labs Ltd, New Drug Discovery Res, New Delhi 110020, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)00009-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new peptoids as endothelin receptor antagonists has been synthesized. Screening them for their ability to bind with endothelin receptors (ETA and ETB) competitively in the presence of (I-125) endothelin led to the discovery of compounds as possible leads with IC(50)s in the low micromolar concentrations. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：555 / 557

页数：3

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