Anti-inflammatory activities of Italian Chestnut and Eucalyptus honeys on murine RAW 264.7 macrophages

被引：9

作者：

Cianciosi, Danila ^{[1
]}

Forbes-Hernandez, Tamara Y. ^{[2
]}

Alvarez-Suarez, Jose M. ^{[3
,4
]}

Ansary, Johura ^{[1
]}

Quinzi, Denise ^{[1
]}

Amici, Adolfo ^{[1
]}

Navarro-Hortal, Maria D. ^{[5
]}

Esteban-Munoz, Adelaida ^{[6
]}

Quiles, Jose Luis ^{[5
,7
]}

Battino, Maurizio ^{[1
,8
]}

Giampieri, Francesca ^{[1
,9
]}

机构：

[1] Polytech Univ Marche, Dept Clin Sci, I-60131 Ancona, Italy

[2] Univ Vigo, Dept Analyt & Food Chem, Nutr & Food Sci Grp, CITACA,CACTI, Vigo, Spain

[3] Univ San Francisco Quito, Colegio Ciencias & Ingn, Dept Ingn Alimentos, Quito 170157, Ecuador

[4] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia

[5] Univ Granada, Fac Pharm, Inst Nutr & Food Technol Jose Mataix Verdu, Biomed Res Ctr,Dept Physiol, Avda Conocimiento S-N, Granada 18100, Spain

[6] Univ Granada, Dept Nutr & Bromatol, Granada 18071, Spain

[7] Univ Europea Atlantico, Res Grp Food Nutr Biochem & Hlth, Santander 39011, Spain

[8] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China

[9] King Abdulaziz Univ, Dept Biochem, Fac Sci, Jeddah, Saudi Arabia

来源：

JOURNAL OF FUNCTIONAL FOODS | 2021年 / 87卷

关键词：

Honey; Inflammation; Mitochondrial respiration; Apoptosis; Wound healing; Antioxidant enzymes; NF-KAPPA-B; NITRIC-OXIDE; PHYSICOCHEMICAL PROPERTIES; MANUKA HONEY; TNF-ALPHA; ANTIOXIDANT; INFLAMMATION; APOPTOSIS; ANTIBACTERIAL; INACTIVATION;

D O I：

10.1016/j.jff.2021.104752

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of this study was to evaluate for the first time the anti-inflammatory effects of chestnut (Castanea sativa) and Eucalyptus (Eucalyptus occidentalis) honeys collected in Italy on murine RAW 264.7 macrophages stressed with the bacterial endotoxin lipopolysaccharide (LPS). Pre-treatment with the two honeys markedly decreased apoptosis and stimulated wound healing in macrophages stressed with LPS, where they also reduced the intracellular levels of ROS and nitrite. Additionally, treatment with LPS decreased the levels of glutathione and suppressed the antioxidant enzyme activities, which were significantly (p < 0.05) increased in the presence of the two honeys, through the modulation of Nrf2 expression; in LPS-stressed macrophages, Chestnut or Eucalyptus honeys protected against inflammation by regulating the main inflammatory biomarkers, including TNF-alpha, IL-10 and iNOS, through the decrease of NF-KB expression. Finally, they improved mitochondrial respiration and the main related parameters.

引用

页数：14

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