Functions of miRNAs during Mammalian Heart Development

被引:33
|
作者
Yan, Shun [1 ]
Jiao, Kai [1 ]
机构
[1] Univ Alabama Birmingham, Dept Genet, Birmingham, AL 35294 USA
关键词
miRNA; Dicer1; cardiogenesis; NEURAL CREST CELLS; CARDIAC PROGENITOR CELLS; PROCESSING ENZYME DICER; CARDIOVASCULAR DEVELOPMENT; CARDIOMYOCYTE PROLIFERATION; TRANSCRIPTION FACTORS; REGULATORY NETWORKS; MIR-17-92; CLUSTER; VALVE DEVELOPMENT; DISEASE;
D O I
10.3390/ijms17050789
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
MicroRNAs (miRNAs) play essential roles during mammalian heart development and have emerged as attractive therapeutic targets for cardiovascular diseases. The mammalian embryonic heart is mainly derived from four major cell types during development. These include cardiomyocytes, endocardial cells, epicardial cells, and neural crest cells. Recent data have identified various miRNAs as critical regulators of the proper differentiation, proliferation, and survival of these cell types. In this review, we briefly introduce the contemporary understanding of mammalian cardiac development. We also focus on recent developments in the field of cardiac miRNAs and their functions during the development of different cell types.
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页数:8
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