Effect of polysorbates on atenolol release from film-coated tablets

被引：0
|
作者：
Samani, SM [1 ]
Adrangui, M [1 ]
Farid, DJ [1 ]
Nokhodchi, A [1 ]
机构：
[1] Tabriz Med Sci Univ, Sch Pharm, Dept Pharmaceut, Tabriz, Iran
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 04期
关键词：
D O I：
10.1081/DDC-100102201
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effects of different concentrations of various polysorbates on the release rate of atenolol from film-coated tablets were evaluated. The release profile of atenolol showed that increasing the concentration of polysorbate resulted in an increase in the release rate of atenolol. The type of polysorbate had less effect on the release rate of atenolol. This study revealed that the release kinetic of atenolol from these film-coated tablets was a function of polysorbate concentration. Correlation coefficients of kinetic models could not solely determine the suitability of the models; the sum of the least square of differences also should be calculated when different kinetic models have similar correlation coefficients.
引用
收藏
页码：513 / 516
页数：4
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