Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds

被引：12

作者：

Bouchard, Alexanne ^{[1
,2
]}

Kairouz, Vanessa ^{[1
,2
]}

Manneveau, Maxime ^{[3
]}

Xiong, Heng-Ying ^{[3
]}

Besset, Tatiana ^{[3
]}

Pannecoucke, Xavier ^{[3
]}

Lebel, Helene ^{[1
,2
]}

机构：

[1] Univ Montreal, Dept Chem, POB 6128, Montreal, PQ, Canada

[2] Univ Montreal, Continuous Flow Synth Lab, POB 6128, Montreal, PQ, Canada

[3] Normandie Univ, INSA Rouen, CNRS, UNIROUEN,COBRA,UMR 6014, F-76000 Rouen, France

来源：

JOURNAL OF FLOW CHEMISTRY | 2019年 / 9卷 / 01期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

Aminoquinoline; Bidentate directing group; C-SCF3; bond; Organofluorine compounds; Flow process; C-H activation; Halogenation; Trifluoromethylthioethers; FUNCTIONALIZATION; ACTIVATION;

D O I：

10.1007/s41981-018-0023-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A continuous flow process for the synthesis of trifluoromethylthioethers is reported. The palladium-catalyzed C-H trifluoromethylthiolation of amides derived from the 8-aminoquinoline using N-[(trifluoromethyl)thio]phthalimide produced the desired products in moderate to good yields with a residence time of 20 min. In comparison with the batch process, the reaction time was decreased by a factor of 100 to 200, demonstrating the positive effect of continuous flow processes for this type of reaction.

引用

页码：9 / 12

页数：4

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