Immortalized Adult Rodent Schwann Cells as In Vitro Models to Study Diabetic Neuropathy

被引:22
|
作者
Sango, Kazunori [1 ]
Yanagisawa, Hiroko [1 ]
Takaku, Shizuka [1 ]
Kawakami, Emiko [1 ]
Watabe, Kazuhiko [1 ]
机构
[1] TokyoMetropolitan Inst Med Sci, Dept Sensory & Motor Syst, ALS Neuropathy Project, Setagaya Ku, Tokyo 1568506, Japan
关键词
GLYCATION END-PRODUCTS; NERVE GROWTH-FACTOR; OXIDATIVE STRESS; ALDOSE REDUCTASE; HIGH GLUCOSE; POLYOL PATHWAY; PERIPHERAL NEUROPATHY; AXONAL REGENERATION; CONDUCTION-VELOCITY; GENE-EXPRESSION;
D O I
10.1155/2011/374943
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We have established spontaneously immortalized Schwann cell lines from normal adult mice and rats and murine disease models. One of the normal mouse cell lines, IMS32, possesses some biological properties of mature Schwann cells and high proliferative activities. The IMS32 cells under hyperglycemic and/or hyperlipidemic conditions have been utilized to investigate the pathogenesis of diabetic neuropathy, especially the polyol pathway hyperactivity, glycation, increased oxidative stress, and reduced synthesis of neurotrophic factors. In addition to the mouse cell lines, our current study focuses on the characterization of a normal rat cell line, IFRS1, under normal and high glucose conditions. These Schwann cell lines can be valuable tools for exploring the detailed mechanisms leading to diabetic neuropathy and novel therapeutic approaches against that condition.
引用
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页数:9
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