Newly reported alkaloids produced by marine-derived Penicillium species (covering 2014-2018)

被引:48
|
作者
Zhang, Peng [1 ]
Wei, Qian [2 ]
Yuan, Xiaolong [1 ]
Xu, Kuo [1 ]
机构
[1] Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China
[2] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Penicillium; Alkaloid; Marine fungus; Biological activity; Biosynthesis; PRENYLATED INDOLE ALKALOIDS; NATURAL-PRODUCTS; DIKETOPIPERAZINE ALKALOIDS; SECONDARY METABOLITES; STRUCTURAL DIVERSITY; FUNGUS; DERIVATIVES; MECHANISMS; PEPTIDES; MUTANT;
D O I
10.1016/j.bioorg.2020.103840
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alkaloids, especially heterocyclic alkaloids, have received remarkable attention due to their intriguing structures and potential pharmacological activities. The marine fungi residing in extreme environmental conditions are among the richest sources of these basic nitrogen-containing compounds. Fungal species belonging to the genus Penicillium have been studied worldwide for their biosynthetic potential for generating bioactive alkaloids. This paper offers a systematic review of the newly reported alkaloids produced by marine-derived Penicillium species over the past five years (covering the literature from the beginning of 2014 through the end of 2018) and describes the structural diversity, biological activities, and plausible biosynthetic pathway of the reported compounds. A total of 106 alkaloids and 81 references are included in this review, which is expected to be beneficial for drug development and biosynthesis in the near future.
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页数:14
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