Influence of methylfenpropidine on growth, sterol content and fatty acid composition of Candida albicans

被引：0
|
作者：
Sajbidor, J [1 ]
Breierová, E
Lamacka, M
Bohov, P
机构：
[1] Slovak Univ Technol Bratislava, Dept Biochem Technol, Bratislava 81237, Slovakia
[2] Slovak Acad Sci, Inst Chem, Bratislava 84238, Slovakia
[3] Slovak Acad Sci, Inst Expt Endocrinol, SK-83306 Bratislava, Slovakia
来源：
FOLIA MICROBIOLOGICA | 2000年 / 45卷 / 04期
关键词：
D O I：
10.1007/BF02817553
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The effect of methylfenpropidine on growth, lipid contents, sterol and fatty acid composition was investigated in 5 strains of Candida albicans. The sensitivity of the strains decreased in the order: wild strains > erg(+) ade nys(R) > ade nys(R) erg (defective Delta (8-7)-isomerase) > ade nys(R) erg (defective Delta (5)-desaturase). The presence of the inhibitor influenced fecosterol isomerization, episterol dehydrogenation, zymosterol transmethylation, ignosterol reduction and squalene epoxidation. Methylfenpropidine also induced changes in fatty acid composition, causing a reduction of the palmitic and oleic acid content with a concomitant elevation of stearic, linoleic and linolenic acid levels. The lipid unsaturation index slightly increased. Morphological changes of wild strains were observed after the fungicide treatment.
引用
收藏
页码：313 / 319
页数：7
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