Anticandidal Activity of the Essential Oil of Nepeta transcaucasica Grossh.

被引：11
|
作者：
Iscan, Gokalp [1 ]
Kose, Y. Bulent [2 ]
Demirci, Betul [1 ]
Baser, K. Husnu Can [1 ,3 ]
机构：
[1] Anadolu Univ, Fac Pharm, Dept Pharmacognosy, TR-26470 Eskisehir, Turkey
[2] Anadolu Univ, Fac Pharm, Dept Pharmaceut Bot, TR-26470 Eskisehir, Turkey
[3] King Saud Univ, Fac Sci, Dept Bot & Microbiol, Riyadh, Saudi Arabia
来源：
CHEMISTRY & BIODIVERSITY | 2011年 / 8卷 / 11期
关键词：
Nepeta transcaucasica; Essential oils; Anticandidal properties; ANTIMICROBIAL ACTIVITY; CONSTITUENTS;
D O I：
10.1002/cbdv.201100091
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hydrodistallation of the aerial parts of Nepeta transcaucasica Grossh. (Lamiaceae), collected in Agri, Dogubayazit Province, afforded an essential oil that was characterized by GC and GC/MS analyses. Twenty-seven compounds, representing 97.69% of the total oil composition, were identified, and 4aa,7a,7a beta-nepetalactone (1; 39%), 4aa,7a,7aa-nepetalactone (2; 28%), and germacrene D (3; 15%) constituted the major components. The anticandidal effects of the oil were evaluated against seven Candida strains by using the broth microdilution method. The oil showed good inhibitory effects against C. glabrata and C. tropicalis at minimal inhibitory concentrations (MICs) of 0.09 and 0.375 mg/ml, respectively.
引用
收藏
页码：2144 / 2148
页数：5
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