ACE Inhibitory Peptide from Skin Collagen Hydrolysate of Takifugu bimaculatus as Potential for Protecting HUVECs Injury

被引：21
|
作者：
Cai, Shuilin [1 ,2 ]
Pan, Nan [2 ]
Xu, Min [2 ,3 ]
Su, Yongchang [1 ,2 ]
Qiao, Kun [2 ]
Chen, Bei [2 ]
Zheng, Bingde [1 ]
Xiao, Meitian [1 ]
Liu, Zhiyu [2 ]
机构：
[1] Huaqiao Univ, Coll Chem Engn, Xiamen 361021, Peoples R China
[2] Fisheries Res Inst Fujian, Key Lab Cultivat & High Value Utilizat Marine Org, Xiamen 361013, Peoples R China
[3] Jimei Univ, Coll Food & Biol Engn, Xiamen 361021, Peoples R China
来源：
MARINE DRUGS | 2021年 / 19卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Takifugu bimaculatus; skin collagen; HUVECs; antihypertension; VEIN ENDOTHELIAL-CELLS; VASCULAR OXIDATIVE STRESS; ANGIOTENSIN-II; NITRIC-OXIDE; SIGNALING PATHWAY; DYSFUNCTION; APOPTOSIS; ACTIVATION; NRF2; ENOS;
D O I：
10.3390/md19120655
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Angiotensin-I-converting enzyme (ACE) is a crucial enzyme or receptor that catalyzes the generation of potent vasopressor angiotensin II (Ang II). ACE inhibitory peptides from fish showed effective ACE inhibitory activity. In this study, we reported an ACE inhibitory peptide from Takifugu bimaculatus (T. bimaculatus), which was obtained by molecular docking with acid-soluble collagen (ASC) hydrolysate of T. bimaculatus. The antihypertensive effects and potential mechanism were conducted using Ang-II-induced human umbilical vein endothelial cells (HUVECs) as a model. The results showed that FNLRMQ alleviated the viability and facilitated apoptosis of Ang-II-induced HUVECs. Further research suggested that FNLRMQ may protect Ang-II-induced endothelial injury by regulating Nrf2/HO-1 and PI3K/Akt/eNOS signaling pathways. This study, herein, reveals that collagen peptide FNLRMQ could be used as a potential candidate compound for antihypertensive treatment, and could provide scientific evidence for the high-value utilization of marine resources including T. bimaculatus.
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页数：16
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