Radiosensitizing properties of magnetic hyperthermia mediated by superparamagnetic iron oxide nanoparticles (SPIONs) on human cutaneous melanoma cell lines

被引:36
|
作者
Rybka, Jakub Dalibor [1 ]
机构
[1] Adam Mickiewicz Univ, Ctr Adv Technol, Ul Umultowska 89C, PL-61614 Poznan, Poland
关键词
Melanoma; Superparamagnetic iron oxide nanoparticles; Radiosensitization; RADIATION-THERAPY; MACROMOLECULAR THERAPEUTICS; IN-VITRO; INTERNALIZATION;
D O I
10.1016/j.rpor.2019.01.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Melanoma is responsible for the majority of deaths related to skin cancer. Worryingly, prognoses show an increasing number of melanoma cases each year worldwide. Radiotherapy, which is a cornerstone of cancer treatment, has proved to be useful but insufficient in melanoma management due to exceptionally high radioresistance of melanoma cells. This problem could be overcome by superparamagnetic iron oxide nanoparticles (SPIONs) used as heat mediators in magnetic hyperthermia, which not only enhance radiosensitivity, but also enable precise targeting by exploitation of their magnetic properties. (C) 2019 Greater Poland Cancer Centre. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:152 / 157
页数:6
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