Naive CD4+T Cells Modified to Express a ROR1-Specific CAR Mediate Anti-Tumor Activity and Provide Superior Help to CD8+ROR1-CAR T Cells

被引:0
|
作者
Hudecek, Michael [1 ]
Lupo-Stanghellini, Maria-Teresa [1 ]
Kosasih, Paula [1 ]
Bet, Jeannette [1 ]
Paszkiewicz, Paulina [1 ]
Maloney, David G. [1 ]
Jensen, Michael C. [2 ]
Rader, Christoph [3 ]
Riddell, Stanley R. [1 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
[2] Seattle Childrens Res Inst, Ctr Childhood Canc Res, Seattle, WA USA
[3] NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:294 / 294
页数:1
相关论文
共 50 条
  • [31] Preclinical evaluation of anti-ROR1 CAR T cells employing a ROR1 binding SCFV derived from the clinical stage mab cirmtuzumab
    Prussak, Charles E.
    Oh, Christopher
    Lujan, Juliana Velez
    Lam, Sharon
    Zhang, Jieyu
    Fernandez, Jayde
    Sinha, Navyaa
    Pham, Jessica
    Shi, Haoming
    Shin, Caitlin
    Kaufman, Gunnar F.
    Widhopf, George F., II
    Cohen, Ezra E. W.
    Kipps, Thomas J.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (05)
  • [32] Differential modulation of the PD-1 pathway impacts the anti-tumor activity of CAR T cells
    Lin, Regina J.
    Gautron, Anne-Sophie
    Poirot, Laurent
    Wong, Oi Kwan
    Sasu, Barbra
    Boldajipour, Bijan
    CANCER RESEARCH, 2017, 77
  • [33] Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells
    Hudecek, Michael
    Lupo-Stanghellini, Maria-Teresa
    Kosasih, Paula L.
    Sommermeyer, Daniel
    Jensen, Michael C.
    Rader, Christoph
    Riddell, Stanley R.
    CLINICAL CANCER RESEARCH, 2013, 19 (12) : 3153 - 3164
  • [34] CD4 CAR T Cells Mediate CD8-like Cytotoxic Anti-Leukemic Effects Resulting in Leukemic Clearance and Are Less Susceptible to Attenuation By Endogenous TCR Activation Than CD8 CAR T Cells
    Yang, Yinmeng
    Lin, Tasha
    Jacoby, Elad
    Qin, Haiying
    Gardner, Elizabeth Grier
    Chien, Christopher Daniel
    Lee, Daniel W., III
    Fry, Terry J.
    BLOOD, 2015, 126 (23)
  • [35] The anti-tumor function of ROR1-CAR modified T-cells against triple-negative breast cancer is enhanced by shielding from immunosuppressive TGF-β
    Stueber, T.
    Wallstabe, L.
    Rydzek, J.
    Nerreter, T.
    Woeckel, A.
    Einsele, H.
    Wischhusen, J.
    Hudecek, M.
    ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 7 - 7
  • [36] Unedited CD7 CAR T-Cells Overcome Fratricide and Produce Superior Anti-Tumor Activity in a Preclinical Model of T-Cell Leukemia
    Watanabe, Norihiro
    Mo, Feiyan
    Ma, Royce
    Srinivasan, Madhuwanti
    McKenna, Mary K.
    Scherer, Lauren D.
    Mamonkin, Maksim
    MOLECULAR THERAPY, 2021, 29 (04) : 302 - 303
  • [37] Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer
    Stuber, Tanja
    Monjezi, Razieh
    Wallstabe, Lars
    Kuehnemundt, Johanna
    Nietzer, Sarah Louise
    Dandekar, Gudrun
    Woeckel, Achim
    Einsele, Hermann
    Wischhusen, Joerg
    Hudecek, Michael
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)
  • [38] Ocular melanoma cells genetically modified to express HLA-DR and CD80 activate tumor-specific CD4+T cells
    Bosch, Jacobus J.
    Thompson, James A.
    Dissanayake, Samudra K.
    Ksander, Bruce R.
    Ostrand-Rosenberg, Suzanne
    JOURNAL OF IMMUNOLOGY, 2006, 176 : S258 - S258
  • [39] Unhelpful CD4 help: Removal of conventional CD4+T cells promotes priming of tumor antigen-specific CD8 T cells in the context of CD4-depletion therapy
    Dragnev, Christo P. C.
    Ramirez, Delaney E.
    Searles, Tyler G.
    Spicer, Nathaniel
    Chen, TIffany
    Lines, J. Louise
    Hawkes, Aaron R.
    Davis, Wilson L., III
    Mohamed, Asmaa
    Shirai, Keisuke
    Phillips, Joesph D.
    Rosato, Pamela C.
    Huang, Yina H.
    Turk, Mary Jo
    CANCER IMMUNOLOGY RESEARCH, 2024, 12 (10)
  • [40] MALT1-induced Roquin cleavage in T cells and CAR T cells is critical for anti-tumor immunity
    Negraschusl, Arlinda
    Holtermann, Anne
    Edelmann, Stephanie
    Rupp, Luise
    Fuechsl, Franziska
    Krackhardt, Angela
    Schmitz, Marc
    Kobold, Sebastian
    Heissmeyer, Vigo
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 340 - 340