Polymorphisms C677T and A1298C in the MTHFR gene in Mexican patients with rheumatoid arthritis treated with methotrexate: implication with elevation of transaminases

被引:29
|
作者
Mena, J. P. [1 ]
Salazar-Paramo, M. [2 ,3 ]
Gonzalez-Lopez, L. [4 ]
Gamez-Nava, J. I. [2 ,3 ,4 ]
Sandoval-Ramirez, L. [5 ]
Sanchez, J. D. [4 ]
Figuera, L. E. [5 ]
Munoz-Valle, F. J. [6 ]
Vazquez del Mercado, M. [6 ]
Davalos, I. P. [1 ,5 ]
机构
[1] Univ Guadalajara, CUCS, Inst Human Genet, Guadalajara 44430, Jalisco, Mexico
[2] Univ Guadalajara, CUCS, Dept Fisiol, Guadalajara 44430, Jalisco, Mexico
[3] Univ Guadalajara, Div Invest,IMSS, CMNO, Unidad Invest Epidemiol Clin,Hosp Especialidades, Guadalajara 44430, Jalisco, Mexico
[4] HGR 110, IMSS, Dept Med Interna Reumatol, Guadalajara, Jalisco, Mexico
[5] CIBO, IMSS, Div Genet, Guadalajara 44340, Jalisco, Mexico
[6] Univ Guadalajara, CUCS, Inst Invest Reumatol & Sistema Musculoesquelet, Guadalajara 44430, Jalisco, Mexico
来源
PHARMACOGENOMICS JOURNAL | 2011年 / 11卷 / 04期
关键词
methotrexate; transaminases; pharmacogenetics; rheumatoid arthritis; MTHFR; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; SINGLE-NUCLEOTIDE POLYMORPHISMS; RISK-FACTOR; COMMON MUTATION; VARIANT;
D O I
10.1038/tpj.2010.32
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Rheumatoid arthritis (RA) is the prototype of the rheumatic diseases worldwide. Methotrexate (MTX) is the drug of first choice in the treatment of this disease due to its immunosuppressant effect. However, side events are present in 30% of the patients. The C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene are involved in the metabolism of MTX. Earlier studies reported an association between these polymorphisms and elevation of hepatic enzymes. We analyzed the frequencies of both polymorphisms and the presence of transaminasemia in 70 Mexican patients with rheumatic arthritis treated with MTX. The 19% (13/70) of patients had an increase in the serum level of transaminases. The A1298C polymorphism was associated with elevation of transaminases (P = 0.024). The identification of MTHFR genotypes for C677T and A1298C polymorphisms could lead clinicians to identify patients in risk of elevation of transaminases, and give them an individualized treatment, as is a goal of pharmacogenetics. The Pharmacogenomics Journal (2011) 11, 287-291; doi:10.1038/tpj.2010.32; published online 1 June 2010
引用
收藏
页码:287 / 291
页数:5
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