Copper-Catalyzed Aerobic Oxidation of Azinylmethanes for Access to Trifluoromethylazinylols

被引：21
|
作者：
Zheng, Gang [1 ]
Liu, Hao [1 ]
Wang, Mang [1 ]
机构：
[1] Northeast Normal Univ, Dept Chem, Changchun 130024, Jilin, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2016年 / 34卷 / 05期
基金：
中国国家自然科学基金;
关键词：
aerobic oxidation; azinylmethanes; copper catalysis; synthetic methods; trifluoromethylation; SELECTIVE OXIDATION; EFFICIENT SYNTHESIS; DIRECT AMIDATION; FUNCTIONALIZATION;
D O I：
10.1002/cjoc.201500918
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-catalyzed oxygenation of methylazaarenes was found to occur in the absence of both ligand and additive, and has been successfully employed for the synthesis of trifluoromethylazinylketols. This synthetic strategy incorporates aerobic oxidation and a trifluoromethylation in one-pot and provides a novel method for the trifluoromethylation of aliphatic C-H bond.
引用
收藏
页码：519 / 523
页数：5
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