Optimizing Retinal Ganglion Cell Responses to High-Frequency Electrical Stimulation Strategies for Preferential Neuronal Excitation

被引：0

作者：

Guo, Tianruo ^{[1
]}

Lovell, Nigel H. ^{[1
]}

Tsai, David ^{[1
,2
]}

Twyford, Perry ^{[4
,5
,6
]}

Fried, Shelley ^{[4
,5
,6
]}

Morley, John W. ^{[3
]}

Suaning, Gregg J. ^{[1
]}

Dokos, Socrates ^{[1
]}

机构：

[1] UNSW Australia, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia

[2] Columbia Univ, Howard Hughes Med Inst, Biol Sci & Bioelect Syst Lab, Elect Engn, New York, NY 10032 USA

[3] Univ Western Sydney, Sch Med, Penrith, NSW 1797, Australia

[4] VA Boston Healthcare Syst, Boston, MA USA

[5] Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA

[6] Harvard Univ, Sch Med, Boston, MA USA

来源：

2015 7TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER) | 2015年

关键词：

TIGER SALAMANDER RETINA; MECHANISMS; SIMULATION;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A retinal ganglion cell (RGC) model based on accurate biophysics and detailed representations of cell morphologies was used to understand how these cells respond to electrical stimulation over a wide range of frequencies, spanning 50-2000 pulses per second (PPS). Our modeling results and associated in vitro data both suggest the usefulness of high stimulation frequency in effectively modulating the activity of RGCs. This model can be used for optimizing varied extracellular stimulus profiles, and to assist in the design of sophisticated stimulation strategies for clinical visual neuroprostheses.

引用

页码：252 / 255

页数：4

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