Experience with high frequency oscillation ventilation during the 2009 H1N1 influenza pandemic in Australia and New Zealand

被引：6

作者：

Boots, R. J. ^{[1
,2
]}

Lipman, J. ^{[1
,2
]}

Lassig-Smith, M. ^{[1
]}

Stephens, D. P. ^{[3
]}

Thomas, J. ^{[3
]}

Shehabi, Y. ^{[4
]}

Bass, F. ^{[4
]}

Anthony, A. ^{[5
]}

Long, D. ^{[5
]}

Seppelt, I. M. ^{[6
,7
]}

Weisbrodt, L. ^{[6
,7
]}

Erickson, S. ^{[8
]}

Beca, J. ^{[9
]}

Sherring, C. ^{[9
]}

McGuiness, S. ^{[10
]}

Parke, R. ^{[10
]}

Stachowski, E. R. ^{[11
]}

Boyd, R. ^{[11
]}

Howe, B. ^{[12
]}

机构：

[1] Royal Brisbane & Womens Hosp, Dept Intens Care Med, Butterfield St, Herston, Qld 4029, Australia

[2] Univ Queensland, Burns Trauma & Crit Care Res Ctr, Brisbane, Qld, Australia

[3] Royal Darwin Hosp, Dept Intens Care Serv, Darwin, NT, Australia

[4] Prince Wales Hosp, Intens Care Unit, Sydney, NSW, Australia

[5] Royal Childrens Hosp, Brisbane, Qld, Australia

[6] Nepean Hosp, Dept Intens Care Med, Penrith, NSW, Australia

[7] Univ Sydney, Sydney Med Sch Nepean, Sydney, NSW 2006, Australia

[8] Paediat Intens Care Unit, Perth, WA, Australia

[9] Starship Childrens Hosp, Paediat Intens Care Unit, Auckland, New Zealand

[10] Auckland City Hosp, Cardiothorac & Vasc Intens Care Unit, Auckland, New Zealand

[11] Westmead Hosp, Intens Care Unit, Westmead, NSW 2145, Australia

[12] Monash Univ, Sch Publ Hlth & Preventat Med, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic 3004, Australia

来源：

ANAESTHESIA AND INTENSIVE CARE | 2011年 / 39卷 / 05期

关键词：

high frequency oscillation ventilation; influenza; respiratory failure; ACUTE LUNG INJURY; EXTRACORPOREAL MEMBRANE-OXYGENATION; RESPIRATORY-FAILURE; RECRUITMENT MANEUVERS; ADULT; A(H1N1);

D O I：

10.1177/0310057X1103900507

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

During the 2009 H1N1 pandemic, large numbers of patients had severe respiratory failure. High frequency oscillation ventilation was used as a salvage technique for profound hypoxaemia. Our aim was to compare this experience with high frequency oscillation ventilation during the 2009 H1N1 pandemic with the same period in 2008 by performing a three-month period prevalence study in Australian and New Zealand intensive care units. The main study end-points were clinical demographics, care delivery and survival. Nine intensive care units contributed data. During 2009 there were 22 H1N1 patients (17 adults, five children) and 10 non-H1N1 patients (five adults, five children), while in 2008, 18 patients (two adults, 16 children) received high frequency oscillation ventilation. The principal non-H1N1 high frequency oscillation ventilation indication was bacterial or viral pneumonia (56%). For H1N1 patients, the median duration of high frequency oscillation ventilation was 3.7 days (interquartile range 1.8 to 5) with concomitant therapies including recruitment manoeuvres (22%), prone ventilation (41%), inhaled prostacyclins (18%) and inhaled nitric oxide (36%). Seven patients received extracorporeal membrane oxygenation, six having H1N1. Three patients had extracorporeal membrane oxygenation concurrently, two as salvage therapy following the commencement of high frequency oscillation ventilation. In 2008, no high frequency oscillation ventilation patient received extracorporeal membrane oxygenation. Overall hospital survival was 77% in H1N1 patients, while survival in patients having adjunctive extracorporeal membrane oxygenation was similar to those receiving high frequency oscillation ventilation alone (65% compared to 71%, P=1.00). Survival rates were comparable to published extracorporeal membrane oxygenation outcomes. high frequency oscillation ventilation was used successfully as a rescue therapy for severe respiratory failure. high frequency oscillation ventilation was only available in a limited number of intensive care units during the H1N1 pandemic.

引用

页码：837 / 846

页数：10

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