Multidisciplinary Management of Nonresectable Hepatocellular Carcinoma

被引:18
|
作者
Park, Hee Chul [2 ]
Seong, Jinsil [1 ]
Tanaka, Masatoshi [6 ]
Zeng, Zhao-Chong [7 ]
Lim, Ho Yeong [3 ]
Guan, Sheng [8 ]
Bae, Si Hyun [4 ]
Tak, Won Young [5 ]
机构
[1] Yonsei Univ, Coll Med, Yonsei Inst Gastroenterol,Hlth Serv, Dept Radiat Oncol,Yonsei Liver Canc Special Clin, Seoul 120752, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiat Oncol, Seoul, South Korea
[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea
[4] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
[5] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Taegu, South Korea
[6] Kurume Univ, Sch Med, Div Gastroenterol, Dept Med, Kurume, Fukuoka 830, Japan
[7] Fudan Univ, Zhongshan Hosp, Dept Radiat Oncol, Shanghai 200433, Peoples R China
[8] Zhengzhou Univ, Dept Intervent Radiol, Affiliated Hosp 1, Zhengzhou, Peoples R China
关键词
Hepatocellular carcinoma; nonresectable; Hepatitis B virus; Multidisciplinary approach; 3-DIMENSIONAL CONFORMAL RADIOTHERAPY; PERCUTANEOUS ETHANOL INJECTION; PARTIAL SPLENIC EMBOLIZATION; RADIOFREQUENCY ABLATION; COMBINATION THERAPY; JAPAN-SOCIETY; TRANSARTERIAL CHEMOEMBOLIZATION; CONSENSUS RECOMMENDATIONS; PULMONARY METASTASECTOMY; INTERVENTIONAL THERAPIES;
D O I
10.1159/000333276
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This article summarizes the consensus of an early morning workshop on the multidisciplinary management of nonresectable hepatocellular carcinoma (HCC) held on July 4, 2010, under the auspices of the 1st Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE) Scientific Advisory Committee. Important points are as follows: (1) nonresectable HCC consists of locally advanced HCC and HCC with extrahepatic spread. The grouping system for locally advanced HCC comprises the following categories: nodular, massive with intrahepatic metastases, diffuse, and disease with vascular invasion. (2) In actual clinical practice, the orchestration of multimodality treatment options is keenly needed for successful treatment of individual patients with nonresectable HCC. Physicians in charge tend to prefer maximal cytoreductive measures as long as the condition of the individual patient allows. (3) There are a few studies on the combined use of radiation therapy and transcatheter arterial chemoembolization or hepatic arterial infusion chemotherapy in the form of phase I and II trials. (4) At this stage, scientific evidence on multidisciplinary management of nonresectable HCC is lacking. Further studies on multidisciplinary management should focus on the subcategory of locally advanced HCC. (5) Further discussion is needed in the upcoming APPLE meeting to clarify the guidelines as well as to determine a practical multidisciplinary approach for nonresectable HCC patients. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:134 / 140
页数:7
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