Protective effects of green tea against hepatic injury induced by high-cholesterol diet in rats: histopathological analysis, oxidative DNA damage and COX-2 expression
被引:5
|
作者:
de Moraes, Barbara B.
论文数: 0引用数: 0
h-index: 0
机构:
UNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
de Moraes, Barbara B.
[1
]
Pasquini, Gabriela
论文数: 0引用数: 0
h-index: 0
机构:
UNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Pasquini, Gabriela
[1
]
Aguiar, Odair, Jr.
论文数: 0引用数: 0
h-index: 0
机构:
UNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Aguiar, Odair, Jr.
[1
]
Golluecke, Andrea P. B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Catolica Santos, HEXALAB & Nutr Dept, Santos, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Golluecke, Andrea P. B.
[2
]
Ihara, Silvia S. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo, Dept Patol, Sao Paulo, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Ihara, Silvia S. M.
[3
]
Tenorio, Neuli M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo, Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Tenorio, Neuli M.
[4
]
Andersen, Monica L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo, Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Andersen, Monica L.
[4
]
Catharino, Rodrigo R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, Campinas, SP, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Catharino, Rodrigo R.
[5
]
Spadari-Bratfisch, Regina Celia
论文数: 0引用数: 0
h-index: 0
机构:
UNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Spadari-Bratfisch, Regina Celia
[1
]
Ribeiro, Daniel Araki
论文数: 0引用数: 0
h-index: 0
机构:
UNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Univ Fed Sao Paulo, Dept Patol, Sao Paulo, BrazilUNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
Ribeiro, Daniel Araki
[1
,3
]
机构:
[1] UNIFESP, Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
[2] Univ Catolica Santos, HEXALAB & Nutr Dept, Santos, Brazil
[3] Univ Fed Sao Paulo, Dept Patol, Sao Paulo, Brazil
[4] Univ Fed Sao Paulo, Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
[5] Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, Campinas, SP, Brazil
Purpose The goal of this study was to investigate whether daily administration of green tea is able to protect the liver injury induced by cholesterol. Methods Male Wistar rats (n = 24) were distributed into four groups: group 1, negative control; group 2, cholesterol at 1% (w/w) in the diet treated for 5 weeks; group 3, cholesterol at 1% treated for 5 weeks and green tea at 1% (w/v) in drinking water in the last week only and group 4, cholesterol and green tea at 1% in drinking water for 5 weeks. Results The results pointed out that treatment with green tea in the last week (group 3) showed mild degenerative changes of liver tissue in cholesterol exposed group when compared to group 2. Green tea aqueous extract was not able to reduce cholesterol levels, that is, no significant statistical differences (p > 0.05) were noticed when compared to positive control group. Nevertheless, green tea was able to decrease oxidative deoxyribonucleic acid (DNA) damage either to peripheral blood or to liver cells as depicted by significant statistical differences (p < 0.05) in the mean tail moment between groups treated with green tea and cholesterol and cholesterol only. Furthermore, histomorphometric analysis of COX-2 expression revealed that in groups exposed to green tea they were significantly decreased (p < 0.05), regardless of time exposure adopted. Conclusion Taken together, our results suggest that daily administration of green tea for at least 7 days displays some preventive properties as indicated by COX-2 downregulation and decreased oxidative DNA damage.
机构:
King Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi Arabia
Albasher, Gadah
Alwahaibi, Mona
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi Arabia
Alwahaibi, Mona
Abdel-Daim, Mohamed M.
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi Arabia
Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia 41522, EgyptKing Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi Arabia
Abdel-Daim, Mohamed M.
论文数: 引用数:
h-index:
机构:
Alkahtani, Saad
Almeer, Rafa
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi ArabiaKing Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi Arabia
机构:
China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R China
Liu, W.
Xu, Z.
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R China
Xu, Z.
Li, H.
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R China
Li, H.
Guo, M.
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R China
Guo, M.
Yang, T.
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R China
Yang, T.
Feng, S.
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R China
Feng, S.
Xu, B.
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R China
Xu, B.
Deng, Yu
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110001, Liaoning, Peoples R China