Lipid Emulsion in Treatment of Local Anesthetic Toxicity

被引：8

作者：

Collins, Shawn ^{[1
]}

Neubrander, Judy ^{[2
]}

Vorst, Zachary ^{[3
]}

Sheffield, Brad ^{[3
]}

机构：

[1] Western Carolina Univ, Nurse Anesthesia Program, Cullowhee, NC 28723 USA

[2] Western Carolina Univ, Sch Nursing, Cullowhee, NC 28723 USA

[3] Western Carolina Univ, Anesthesia Program, Cullowhee, NC 28723 USA

来源：

JOURNAL OF PERIANESTHESIA NURSING | 2015年 / 30卷 / 04期

关键词：

local anesthetic; toxicity; lipid rescue; lipid emulsion; regional anesthesia; INDUCED CARDIAC-ARREST; CENTRAL-NERVOUS-SYSTEM; SUCCESSFUL RESUSCITATION; CARDIOVASCULAR COLLAPSE; PLEXUS BLOCK; BUPIVACAINE; OVERDOSE; INFUSION; PATIENT; ROPIVACAINE;

D O I：

10.1016/j.jopan.2014.03.011

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

Epidural, spinal, regional, local, and intravenous administration of local anesthetics (LAs) is a cornerstone of anesthetic practice. LA toxicity is a grave consequence that is of great significance to anesthesia providers. Outcomes of LA toxicity range from inconvenient symptoms such as tinnitus, twitching, and hypotension to seizures; cardiovascular or respiratory collapse; and death. Lipid emulsion has emerged as a potential "magic bullet" in treating LA toxicity. This literature review provides background information and proposed mechanisms of action for LAs and lipid emulsion as well as animal experiments and a case report that speak to the effectiveness of lipid emulsion in the face of LA toxicity. (C) 2015 by American Society of PeriAnesthesia Nurses

引用

页码：308 / 320

页数：13

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