Gadolinium-binding helix-turn-helix peptides: DNA-dependent MRI contrast agents

被引：47
|
作者：
Caravan, P
Greenwood, JM
Welch, JT
Franklin, SJ [1 ]
机构：
[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA
[2] EPIX Med Inc, Cambridge, MA 02142 USA
来源：
CHEMICAL COMMUNICATIONS | 2003年 / 20期
关键词：
D O I：
10.1039/b307817e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A de novo designed gadolinium metallopeptide was found to be a very efficient relaxation agent, with 100% increase in relaxivity upon binding to DNA.
引用
收藏
页码：2574 / 2575
页数：2
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