Gadolinium-binding helix-turn-helix peptides: DNA-dependent MRI contrast agents

被引：47

作者：

Caravan, P

Greenwood, JM

Welch, JT

Franklin, SJ ^{[1
]}

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

[2] EPIX Med Inc, Cambridge, MA 02142 USA

来源：

关键词：

D O I：

10.1039/b307817e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A de novo designed gadolinium metallopeptide was found to be a very efficient relaxation agent, with 100% increase in relaxivity upon binding to DNA.

引用

页码：2574 / 2575

页数：2

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