On the design of polymeric 5′-O-ester prodrugs of 3′-azido-2′,3′-dideoxythymidine (AZT)

被引：20

作者：

Troev, Kolio D. ^{[1
]}

Mitova, Violeta A. ^{[1
]}

Ivanov, Ivan G. ^{[2
]}

机构：

[1] Bulgarian Acad Sci, Inst Polymers, Sofia, Bulgaria

[2] Bulgarian Acad Sci, Inst Expt Pathol & Parasitol, Sofia, Bulgaria

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 47期

关键词：

Poly(oxyethylene H-phosphonate)s; Polymer conjugates; Anti-HIV prodrugs; Toxicity; AZT; 5'-O-HYDROGEN PHOSPHOLIPIDS; IMMOBILIZATION; AMINOTHIOLS;

D O I：

10.1016/j.tetlet.2010.09.076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new 5'-O-AZT prodrug was synthesized by conjugating 3'-azido-2',3'-dideoxythymidine (AZT) with poly(oxyethylene H-phosphonate) at room temperature under Atherton-Todd reaction conditions. The acute toxicity of poly(5'-O-AZT-oxyethylene phosphate) was reduced significantly in comparison with non-immobilized AZT. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6123 / 6125

页数：3

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